Advances in Traditional Medicine

  • 제6권4호
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  • Pages.253-263
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  • 2006
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Bacopa monniera

  • 발행 : 2006.12.31
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초록

The plant is used in India as well as several countries since several centuries for treating different types of ailments. The plant is an important constituent of the Ayurvedic Materia Medica and finds mention in several ancient texts including Caraka Sanhita ($6^{th}$ century A.D.) and the Bhavprakasa ($16^{th}$ century A.D.). The scientific studies on this plant have reported several activities of this plant. Though the plant has cardiotonic, vasoconstrictor, sedative, neuro-muscular blocking, and anticancer activities, it is more popular as memory enhancer. Traditionally, a poultice made of the boiled plant is placed on the chest in acute bronchitis and coughs of children. The plant contains saponins: bacosides A and B, hersaponin, sapogenins: bacogenin $A_{1}$, $A_{2}$, and $A_{3}$ stigmasterol, and flavonoids: luteolin and luteolin-7 glucoside, nicotine, brahmine, and herpestine. This review focuses on the scientific data published since 1931.

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참고문헌

  1. Abhang R. (1993) Studies to evaluate the effect of micro medicine derived from Brahmi (Herpestis monniera) on students of average intelligence. J. Res. Ayur. Siddha. 14, 10-24.
  2. Agrawal A. (1993) A comparative study of psychotropic drugs and bio-feedback therapy in the prevention and management of psychosomatic disorder (thesis). Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
  3. Aithal HN, Sirsi M. (1961) Pharmacological Investigations on Herpestis monniera H.B. & K. Indian J. Pharmacol. 23, 2-5.
  4. Anonymous. (1988) Wealth of India, Raw Materials, National Institute of Science Communication, New Delhi, India. 2B, pp. 2-3.
  5. Arora D, Kumar M, Dubey SD. (2002) Singh U. Immunomodulating effects of Rasayana drugs in diabetics - A clinical study. Ancient Science of Life. XXII, p. 42-48.
  6. Banerjee SK, Chakravarti RN. (1963) Stigmasterol from Herpestis monniera. Bull. Calcutta Sch. Trap. Med. 11, 57-58.
  7. Basu N, Rastogi RP, Dhar ML. (1967) Chemical examination of Bacopa monniera Wettest Part III. Bacoside B. Indian J. Chem. 5, 84-86.
  8. Bhardwaj SK, Srivastav KK. (1995) Effect of composite Indian herbal preparation, CIHP(III) on avoidance learning during endurance performance in rats. Indian J. Exp. Biol. 33, 580-584.
  9. Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S. (2000) Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum, and hippocampus. Phytother. Res. 14, 174-179. https://doi.org/10.1002/(SICI)1099-1573(200005)14:3<174::AID-PTR624>3.0.CO;2-O
  10. Bhattacharya SK, Ghosal S. (1998) Anxiolytic activity of a standardized extract of Bacopa monniera: an experimental study. Phytoedicine 5, 77-82.
  11. Bhattacharya SK, Kumar A, Ghosal S. (2001) Effect of Bacopa monniera on animal models of Alzheimer’s disease and perturbed central cholinergic markers of cognition in rats. Emerging Drugs, Wesbury, NY, USA, pp 21-32.
  12. Bose KC, Bose NK. (1931) Observations on the actions and uses of Herpestis monniera. J. Indian Med. Asso. 1, 60.
  13. Chakravarti AK, Garai S, Masuda K. (2003) Bacopasides III-IV: the new triterpenoid glycosides from Bacopa monniera. 51, 215-217. https://doi.org/10.1248/cpb.51.215
  14. Chatterji N, Rastogi RP, Dhar ML. (1963) Chemical examination of Bacopa monniera Wettest. Part I. Isolation of chemical constituents. Indian J. Chem. 1, 212.
  15. Chatterji N, Rastogi RP, Dhar ML. (1965) Chemica1 examination of Bacopa monniera Part II. The constitution of Bacoside A. Indian J. Chem. 3, 24.
  16. Chopra RN, Nayar SL, Chopra IC. (1956) Glossary of Indian Medicinal Plants. Council of Scientific and Industrial Research. New Delhi, p. 32.
  17. Chowdhuri DK, Parmar D, Kakkar P, Shukla R, Seth PK, Srimal RC (2002) Antistress effects of Bacosides of Bacopa monniera: Modulation of Hsp70, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother. Res. 16, 639-645. https://doi.org/10.1002/ptr.1023
  18. Chunekar KC. (1960) Bhav Prakash Nighantu, Chaukhamba Bharati Publication, Varanasi, p. 56.
  19. D'Souza P, Deepak M, Rani P, Kadamboor S, Mathew A, Chandrashekhar AP, Agarwal A. (2002) Brine shrimp lethality assay of Bacopa monniera. Phytother. Res. 16, 197-198. https://doi.org/10.1002/ptr.1001
  20. Dar A, Channa S. (1997a) Relaxant effect of ethanol extract of Bacopa monniera on trachea, pulmonary artery and aorta from rabbit and guinea pig. Phytother. Res. 11, 323-325. https://doi.org/10.1002/(SICI)1099-1573(199706)11:4<323::AID-PTR93>3.0.CO;2-H
  21. Dar A, Channa S. (1997b) Bronchodilatory and cardiovascular effects of ethanol extract of Bacopa monniera in anaesthetized rats. Phytomedicine 4, 319-323.
  22. Dar A, Channa S. (1999) Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea pig. J. Ethnopharmacol. 66, 167-174. https://doi.org/10.1016/S0378-8741(98)00240-2
  23. Darshan S, Doreswamy R. (1998) Medicinal Plant patents scenario in the new era of drug development. Indian Drugs 35, 55-66.
  24. Das A, Shanker G, Nath C, Pal R, Singh S, Singh HK. (2002) A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba: Anticholinesterase and cognitive enhancing activity. Pharmacol. Biochem. Behav. 73, 893-900. https://doi.org/10.1016/S0091-3057(02)00940-1
  25. Datta C. (1969) Effects of psychotropic drugs on acetylcholinesterase activity of mouse brain. Indian J. Exp. Biol. 7, 225-228.
  26. Dey CD, Bose S, Mitra S. (1976) Effect of some centrally active phytoproducts on maze learning of albino rats. Indian J. Phys. Allied Sci. 30, 88-97.
  27. Dey PK, Chatterjee BK. (1968) Studies on the neuropharmacolical properties of several Indian medicinal plants. J. Res. Indian Med. 3, 9-17.
  28. Dey PK, Datta C. (1996) Effect of psychotropic phytochemicals on cerebral aino acid level in mice. Indian J. Exp. Biol. 4, 216-218.
  29. Dhalla NS, Sastry MS, Malhotra CL. (1961) Some invitro effects of Herpestis monniera Linn on the respiration of rat brain. Indian J. Med. Res. 49, 781-787.
  30. Dorababu M, Prabha T, Priyambada S, Agrawal VK, Aryya NC, Goel RK. (2004) Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM rats. Indian J. Exp. BioI. 42, 389-397.
  31. Drachman DA, Leavitt J. (1974) Human memory and the cholinergic system. Arch. Neurol. 30, 113-121.
  32. Elangovan V, Govindswamy S, Ramamoorthy N, Balasubramanian K. (1995) In-vitro studies on the anticancer activity of Bacopa monnieri. Fitoterapia 66, 210-215.
  33. Ganguly DK, Malhotra CL. (1967) Some behavioral effects of an active fraction from Herpestis monniera, Linn. (Brahmi). Indian J. Med. Res. 55, 473-482.
  34. Garai S, Mohato SB, Ohtani K, Yamasaki K. (1996) Dammarane type triterpenoid saponin from Bacopa monniera. Phytochemistry 42, 825-820.
  35. Giri AK, Khan KA. (1996) Chromosome aberrations, sister chromatid exchange and micronuclei formation analysis in mice after in vitro exposure to bacoside A and B. Cytology 61, 99-103.
  36. Goel RK, Sairam K, Dora Babu M, Tavares A, Raman A. (2003) In vitro evaluation of Bacopa monniera on anti-Helicobacter pylori activity and accumulation of prostaglandins. Phytomedicine 10, 523-527. https://doi.org/10.1078/094471103322331494
  37. Hou CC, Lin SJ, Cheng JT, Hsu FL. (2002) Bacopaside HI, bacopasaponin G, and bacopaside A, B, and C from Bacopa monniera. J. Nat. Prod. 65, 1759-1763. https://doi.org/10.1021/np020238w
  38. Jagetia GC, Baliga MS. (2003) Treatment of mice with a herbal preparation (Mentat) protects against radiation-induced mortality. Phytother. Res. 17, 876-881. https://doi.org/10.1002/ptr.1142
  39. Jain P, Khanna NK, Trehan N, Pendse VK, Godhwani JL. (1994) Anti-inflammatory effects of an Ayurvedic preparation, Brahmi Rasayan in rodents. Indian J. Exp. Biol. 32, 633-636.
  40. Kapur LD. (1990) Bacopa monniera. CRC Handbook of Ayurvedic Medicinal Plants. CRC press Inc. Boca Raton, Florida, p. 61.
  41. Kar A, Panda S, Bharti S. (2002) Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J. Ethnopharmacol. 81, 281-285. https://doi.org/10.1016/S0378-8741(02)00048-X
  42. Khanna T, Ahemd B. (1992) Beta adrenergic activity of saponins from Bacopa monniera. In Proceedings of the conference on trends in molecular and cellular cardiology, Lucknow, India 4-5 May, p. 20
  43. Kulkarni SK, Verma A. (1993) Br-16A $(Mentat{\circledR})$, a herbal preparation, improves learning and memory performance in mice. Indian Drugs 30, 97-107
  44. Malhotra CL and Das PK. (1959) Pharmacological studies of Herpestis monniera, Linn (Brahmi). Indian J. Med. Res. 47, 294-305.
  45. Malhotra CL, Das PK, Dhalla NS. (1960) Some neuropharmacological actions hersaponin – An active principle from Herpestis monniera Linn. Arch. Int. Pharmacodyn. 129, 290-302
  46. Martis G, Rao A, Karanth KS. (1992) Neuropharmacological activity of Herpestis monniera. Fitoterapia 62, 399-406
  47. Mohato SB, Garai S, Chakravarti AK. (2000) Bacopasaponins E and F: two jujubogenin bisdesmosides from Bacopa monniera. Phytochemistry 53, 711-714. https://doi.org/10.1016/S0031-9422(99)00384-2
  48. Nadkarni KM. (1993) Indian Materia Medica, Bombay, Popular Prakashan, p. 624.
  49. Nadkarni KM. (1954) Indian Materia Medica. Popular Prakashan Pvt. Ltd. Mumbai, India, pp. 624-625.
  50. Nathan PJ, Clark J, Lloyd J, Hutchison CW, Downey L, Stough C. (2001) The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjects. Human Psychopharmacol. Clin. Exp. 16, 345-351. https://doi.org/10.1002/hup.306
  51. Nathan PJ, Tanner S, Lloyd J, Harrison B, Curran L, Oliver C, Stough C. (2004) Effecvts of combined extract of Ginkgo biloba and Bacopa monniera on cognitive function in healthy humans. Human Psychopharmacol. Clin. Exp. 19, 91-96. https://doi.org/10.1002/hup.544
  52. Prakash JC and Sirsi M. (1961) Proc, XXVII Mysore state Med. Conf. Maniupal, India.
  53. Prakash JC and Sirsi M. (1962) Comparative study of the effects of Brahmi (Bacopa monniera) & Chlorpromazine on motor learning in rats. J. Sci. Ind. Res. 21C, 93-96.
  54. Pratico D, Clark CM, Liun F, Lee YM, Trojanowski JQ. (2002) Increase in brain oxidative stress in mild cognitive impairment. Arch. Neurol. 59, 972-976. https://doi.org/10.1001/archneur.59.6.972
  55. Rai D, Bhatia G, Palit G, Pal R, Singh S, Singh HK. (2003) Adaptogenic effect of Bacopa monniera (Brahmi). Pharmacol. Biochem. Behav. 75, 823-830. https://doi.org/10.1016/S0091-3057(03)00156-4
  56. Rao Ch V, Sairam K, Goel RK. (2000) Experimental evaluation of Bacopa monniera on rat gastric ulceration and secretion. Indian J. Physiol. Pharmacol. 44, 435-441.
  57. Rastogi S, Pal R, Kulshreshtha DK. (1994) Bacoside A3 - a triterpenoid saponin from Bacopa monniera. Phytochemistry 36, 133-137. https://doi.org/10.1016/S0031-9422(00)97026-2
  58. Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. (2002) Chronic effects of Brahmi (Bacopa monniera) on human memory. Neuropsychopharmacol. 27, 279-281. https://doi.org/10.1016/S0893-133X(01)00419-5
  59. Russo A, Izzo AA, Borelli F, Renis M, Vanella A. (2003) Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage. Phytother. Res. 17, 870- 875. https://doi.org/10.1002/ptr.1061
  60. Sairam K, Dorababu M, Goel RK, Bhattacharya SK. (2002) Antidepressant activity of Standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine, 9, 207-211. https://doi.org/10.1078/0944-7113-00116
  61. Sairam K, Rao Ch V, Dora BM, Goel RK. (2001) Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine 8, 423-430. https://doi.org/10.1078/S0944-7113(04)70060-4
  62. Sairam K, Rao CV, Babu MD, Goel RK. (2001) Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine 8, 423-430. https://doi.org/10.1078/S0944-7113(04)70060-4
  63. Samiulla DS, Prashanth D, Amit A. (2001) Mast cell stabilizing activity of Bacopa monniera. Fitoterapia 72, 284-285. https://doi.org/10.1016/S0367-326X(00)00309-9
  64. Satyavati GV, Raina MK, Sharma M. (1976) Medicinal plants of India, Vol. 1, ICMR, New Delhi. 118-122.
  65. Schulte KE, Ruecker G, El-Kersch M. (1972) Components of Medicinal Plants. Phytochemistry 11, 2649-2651. https://doi.org/10.1016/S0031-9422(00)88583-0
  66. Shanmugsundaram ERB, Mohammed Akbar GK, Shanmugsundaram KR. (1991) Brahmighritam, an Ayurvedic herbal formula for the control of epilepsy. J. Ethnopharmacol. 33, 269-276. https://doi.org/10.1016/0378-8741(91)90088-U
  67. Singh HK, Dhavan BN. (1997) Neuropsychopharmacological effects of the ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J. Pharmacol. 29, 359-365.
  68. Singh HK, Dhawan BN. (1982) Effect of Bacopa monniera Linn (Brahmi) extract on avoidance responses in rat. J. Ethnopharmacol. 5, 205-214. https://doi.org/10.1016/0378-8741(82)90044-7
  69. Singh HK，Dhawan BN. (1997) Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi) Indian J. Pharmacol. 29, S359-S365.
  70. Singh HK, Rastogi RP, Srimal RC, Dhawan BN. (1988) Effect of Bacoside A and B on avoidance response in rats. Phytother. Res. 2, 70-75. https://doi.org/10.1002/ptr.2650020205
  71. Stough C, Lloyd J, Clark J, Dawney LA. (2001) Hutchison CW, Rodgers T, Nathan PJ. Psycho. Pharmacol. 156, 481-484.
  72. Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ. (2001) The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacogy 156, 481-484. https://doi.org/10.1007/s002130100815
  73. Sumathi Thangrajan, Nayeem M, Balakrishna K, Veluchamy G. Devraj SN. (2002) Alcohoic extract of Bacopa monniera reduces the in vitro effects of morphine withdrawal in guinea pig ileum. J. Ethnopharmacol. 82, 75-81. https://doi.org/10.1016/S0378-8741(02)00139-3
  74. Sumathy T, Subramanian S, Govindaswamy S, Balkrishna K, Veluchamy G. (2001) Protective role of Bacopa monniera on morphine induced hepatotoxicity in rats. Phytother. Res. 15, 643-645. https://doi.org/10.1002/ptr.1007
  75. Tripathi YB, Chaurasia S, Tripathi E, Upadhyaya A, Dubey GP. (1996) Bacopa monniera Linn as an antioxidant: mechanism of action. Indian J. Exp. Biol. 34, 523-526.
  76. Tripathi YB, Pande E, Dubey GP. (1999) Antioxidant property of Hypericum perforatum (L) of Indian origin and its comparison with established Medhya rasayanas of Ayurvedic medicine. Curr. Sci. 76, 27-29.
  77. Um BH, Bouchet MJ, Lobstein A, Callizot N, Maciuk A, Mazars G, Poindron P, Anton R (2002) Bioguided research of nootropic substance from Bacopa monnieri. Revista de Fitoterapia 50th Annual Congress of Society for Medicinal Plant Research S1, 155.
  78. Um BH, Bouchet MJ, Lobstein A, Callizot N, Maciuk A, Mazars G, Poindron P, Anton R (2002) Bioguided research of nootropic substances from Bacopa monnieri. Rev. Fitoterapia 2, S1.
  79. Vohora D, Pal SN, Pillai KK. (2000) Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant. J. Ethnopharmacol. 71, 383-390. https://doi.org/10.1016/S0378-8741(99)00213-5
  80. Vohora SB, Khanna T, Athar M, Ahmad B. (1997) Analgesic activity of bacosine, a new triterpene isolated from Bacopa monniera. Fitoterapia. 68, 361-365.
  81. Vohra BPS, Sharma SP, Kansal VK. (2001) Maharishi Amrit Kalash, an Ayurvedic medicinal preparation, enhances cholinergic enzymes in aged guinea pig brain. Indian J. Exp. Biol. 39, 1258-1262.
  82. Yoganarsimhan SN, Chelladurai V. (2000) Meidicinal Plants of India, Vol. 2. Government Siddha Medical College, Palayamkottai, Tamil Nadu, India, p. 67.