한국한의학연구원논문집 (Korean Journal of Oriental Medicine)
- 제12권3호통권18호
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- Pages.59-67
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- 2006
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- 1229-3377(pISSN)
전침자극이 자연 발증 고혈압 흰쥐의 혈압 조절 중추에서 iNOS의 발현에 미치는 영향
Effects of electroacupuncture on the expression of iNOS in Nuclei of solitary tract and Rostral ventrolateral medulla in spontaneously hypertensive rats
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Hwang, Hye-Suk
(Korea Institute of Oriental Medicine) ;
- Kim, Yu-Sung (Korea Institute of Oriental Medicine) ;
- Lee, Ji-Eun (Korea Institute of Oriental Medicine) ;
- Han, Kyung-Ju (Korea Institute of Oriental Medicine) ;
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Choi, Sun-Mi
(Korea Institute of Oriental Medicine) ;
- Koo, Sung-Tae (Korea Institute of Oriental Medicine)
- 발행 : 2006.12.30
초록
Aims: Acupuncture has been used for the treatment of essential hypertension, but the efficacy and the mechanism of acupuncture in prevention of hypertension are still unclear. We tested the hypothesis that electroacupuncture (EA) applied to Baekhoe (GV20) changes NO/NOS system during development of hypertension in spontaneously hypertensive rats (SHR), and thereby causes the delay of development of hypertension in SHR. Methods: The male SHR rats in the developmental stages of hypertension (7-8 weeks) were randomly divided into three groups (control group, GV20 acupuncture group, and tail acupuncture group). And the age matched Wistar Koyto Rats (WKY) were randomly divided into two groups (nagative control, GV20 acupuncture group). EA treatments (10Hz, 1mA, 0.1ms) were carried out for 25 min/day for five consecutive days. The systolic blood pressure (SBP) was determined in conscious rats by the tail-cuff method using automatic BP mornitoring system. We investigated the activations of inducible NO synthase (iNOS) in nuclei of solitary tract (NTS) and rostral ventrolateral medulla (RVLM) of SHR by the western blotting method. Results: The SBP after the termination of EA stimulation applied to the GV20 was stabilized at
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