Two Cases of Mad-Honey Poisoning with Cardiovascular Symptom

외국산 꿀(석청) 복용후 발생한 심혈관계 중독증상 환자 2례

  • Ko Young-Gil (Department of Emergency Medicine, Inje University Seoul Paik Hospital) ;
  • Kim Kyung-Hwan (Department of Emergency Medicine, Inje University Ilsan Paik Hospital) ;
  • Kim Ah-Jin (Department of Emergency Medicine, Inje University Ilsan Paik Hospital) ;
  • Shin Dong-Wun (Department of Emergency Medicine, Inje University Ilsan Paik Hospital) ;
  • Park Jun-Soek (Department of Emergency Medicine, Inje University Ilsan Paik Hospital) ;
  • Roh Jun-Young (Department of Emergency Medicine, Inje University Ilsan Paik Hospital) ;
  • Ahn Ji-Young (Department of Emergency Medicine, Inje University Seoul Paik Hospital)
  • 고영길 (인제대학교 의과대학 서울백병원 응급의학과) ;
  • 김경환 (일산백병원 응급의학과) ;
  • 김아진 (일산백병원 응급의학과) ;
  • 신동운 (일산백병원 응급의학과) ;
  • 박준석 (일산백병원 응급의학과) ;
  • 노준영 (일산백병원 응급의학과) ;
  • 안지영 (인제대학교 의과대학 서울백병원 응급의학과)
  • Published : 2006.06.01

Abstract

Mad-honey poisoning is mainly brought about by the honey imported from Napal, Turkey, Brazil and other parts of Europe. This mad honey is extracted from Ericaceae plants of Rhododendron species and contains grayanotoxins that causes poisoning. These toxic compounds exert a specific stimulatory action on membrane permeability to Na+ions in various excitable tissues and cause depolarization of cell membranes. The toxic effects of grayanotoxins contained honey are mainly cardiovascular disturbances with bradycardia, cardiac arrhythmia, hypotension. There are Other symptoms like nausea, vomiting, salivation, dizziness, weakness and loss of consciousness. The precise amount for a toxic dose is not known. In general the severity of the honey poisoning depends on the amount ingested. Two cases of mad-honey poisoning are described here. Both patients showed bradycardia and arterial hypotension after ingestion of honey which was brought from Nepal. They were recovered fully within 24 hours after administration of fluids and atropine sulphate.

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