Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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The Effect of Hemoperfusion on Plasma Concentration of Toxins in Acute Pesticide Poisoned Patients

살충제 중독환자에서 혈액관류가 혈중 살충제 농도에 미치는 영향

  • Gil Hyo-Wook (Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital) ;
  • Yang Jong-Oh (Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital) ;
  • Lee Eun-Yong (Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital) ;
  • Hong Sae-Yong (Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital)
  • 길효욱 (순천향대학교 천안병원 농약중독연구소) ;
  • 양종오 (순천향대학교 천안병원 농약중독연구소) ;
  • 이은영 (순천향대학교 천안병원 농약중독연구소) ;
  • 홍세용 (순천향대학교 천안병원 농약중독연구소)
  • Published : 2006.06.01
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Abstract

Purpose: Hemoperfusion is an effective modality of extracorporeal elimination of toxins in acutely poisoned patients. We evaluated the effect of hemoperfusion on plasma concentration of toxins in patients exposed to certain pesticides. Methods: Eleven patients who were acutely exposed to pesticides participated in our study. We measured plasma pesticide concentration from the whole blood obtained by arterial and venous sources by gas chromatography. Results: The plasma concentrations of only 3 patients was measured. Methidation clearance by hemoperfusion was 82.2%, fenitrothion was 23%, and endosulfan was 0% Conclusion: Measurement of plasma organophosphate concentration is not a practical application. Our results suggest that hemoperfusion is applicable in patients with pesticide intoxication according to clinical status.

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