KSTLE International Journal

한국트라이볼로지학회 (Korean Tribology Society)
권호 표지

Study on the Elastic Characteristics of Living Cells using Atomic Force Microscope Indentation Technique

  • Kwon Eun-Young (School of Mechanical Engineering, Yonsei University) ;
  • Kim Young-Tae (School of Mechanical Engineering, Yonsei University) ;
  • Kim Dae-Eun (Department of Mechanical Engineering, Yonsei University)
  • 발행 : 2006.06.01
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초록

In this work, imaging and study of elastic property of the living cell was performed. The motivation of this work was to seek the possibility of exploiting Young's modulus as a disease indicator using Atomic Force Microscope (AFM) and also to gain fundamental understanding of cell mechanics for applications in medical nanorobots of the future. L-929 fibroblast adherent cell was used as the sample. Imaging condition in cell culturing media environment was done in very low speed ($20{\mu}m/ s$) compared to that in the ambient environment. For measuring the Young's modulus of the living cell, AFM indentation method was used. From the force-distance curve obtained from the indentation experiment the Young's modulus could be derived using the Hertz model. The Young's modulus of living L-929 fibroblast cell was $1.29{\pm}0.2$ kPa.

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참고문헌

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