The Journal of Korean Medicine (대한한의학회지)
- Volume 27 Issue 2 Serial No. 66
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- Pages.211-224
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- 2006
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
Effects of Pinelliae Rhizoma on Obese Zucker Rats' Blood Serum Lipids and Skeletal Muscles Fatty Acid Metabolism
반하가 비만 쥐의 혈중지질 및 골격근 내의 지방산 대사에 미치는 영향
- Yun Sang-Gu (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk University) ;
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Kim Ho-Jun
(Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk University) ;
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Lee Myeong-Jong
(Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk University)
- Published : 2006.06.30
Abstract
Objectives : This study was performed to investigate the effects of Pinelliae rhizoma on blood serum lipids and skeletal muscle fatty acid metabolism of obese Zucker rats. Methods : Experimental groups were divided into normal Zucker rats (lean control; non-treated), obese Zucker rats (fat control; non-treated) and Pinelliae rhizoma oral feeding obese Zucker rats (fat control; treated) for 6 separate experiments. Pinelliae rhizoma was investigated for effects on total body weight, serum glucose content, total cholesterol and triglyceride content, free fatty acid content, PPARalpha, CS and beta-HAD. Results : 1. Triglycerides in blood serum showed a greater decrease in the Pinellia rhizoma oral feeding group than the overweight control group. 2. PPARa showed a significant increase in the Pinelliae rhizoma oral feeding group over the overweight control group in skeletal muscles of SOL and EDL: as for protein FABPc, the Pinelliae rhizomaoral feeding group saw a greater significant increase than the overweight control group in the skeletal muscles of SOL. 3. CS activity showed a greater increase for the Pinelliae rhizoma oral feeding group than the overweight control group in EDL Conclusions : As the experiment's results show, Pinelliae rhizoma effectively decreased the weight and triglycerides of the obese mouse, and somewhat affects the fat oxidation in the skeletal muscles.
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