The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Hypoglycemic, Hepatoprotective, and Nephroprotective Effects of - 'Saengjinyanghyul-tang($Sh\={e}ngj\={i}ny\v{a}ngxu\`{e}-t\={a}ng$)' - in Streptozotocin-Induced Diabetic SD Rats

생진양혈탕(生律養血湯)이 Streptozotocin으로 유발된 당뇨병 Rat 모델의 고혈당 및 간병증과 신병증에 미치는 영향

  • Kwak Min-Ah (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kim Min-Su (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Byun Joon-Seok (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
  • 곽민아 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 김민수 (동의대학교 한의과대학 한방재활의학과교실) ;
  • 변준석 (대구한의대학교 한의과대학 비계내과학교실)
  • Published : 2006.06.30
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Abstract

Objectives : This study aimed to evaluate the hypoglycemic, hepatoprotective, and nephroprotective effects of 'Saengjinyanghyul-tang($Sh\={e}ngj\={i}ny\v{a}ngxu\`{e}-t\={a}ng$ : SJYHT)' in streptozotocin (STZ)-induced diabetic SD rat model. Methods : SJYHT extracts were once a day dosed for 28 days at a dosage 1000, 500, and 250mg/kg/5ml from 25 days after STZ-dosing, and the changes on blood glucose levels, liver and kidney weight, serum AST, ALT, BUN and creatinine levels were observed with histological changes on the liver and kidney. Results : Increased blood glucose levels, and diabetic hepatopathy & nephropathy including increased serum AST, ALT, BUN and creatinine levels, histological changes after STZ-dosing were dose-dependently reduced by SJYHT extract-dosing. Conclusions : 'SJYHT' water extracts have favorable hypoglycemic, hepatoprotective, and nephroprotective effects on the STZ-induced diabetic SD rats. Therefore, it is expected that 'SJYHT' has potential for use in the management of diabetes and diabetic complications.

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