Journal of Korean Society for Clinical Pharmacology and Therapeutics (임상약리학회지)

Korean Society for Clinical Pharmacology and Therapeutics (대한임상약리학회)
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Pharmacogenomics in Cancer Treatment

종양학에서 약물유전체학(Pharmacogenomics)

  • Kim, Min-Kyoung (Division of Oncology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Tae-Won (Department of Clinical Pharmacology, Asan Medical Center, University of Ulsan College of Medicine)
  • 김민경 (울산대학교 의과대학 서울아산병원 종양내과) ;
  • 김태원 (울산대학교 의과대학 서울아산병원 임상약리학과)
  • Published : 2006.12.30

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Abstract

Interindividual variability in the efficacy and toxicity of chemotherapy is associated with polymorphisms in genes encoding drug-metabolizing enzymes, transporters, or drug targets. Pharmacogenomics is the study of the hereditary basis of these interindividual differences and aims to identify genetic factors to predict toxicity and therapeutic outcomes. There exist several clinically relevant examples of the utility of pharmacogenomics that associate specific genetic polymorphisms in drug metabolizing enzymes and drug target enzymes. This review discusses the current and future applications of pharmacogenomics in clinical cancer therapy.

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