The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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Transdermal Permeation Effects of Lidocaine HCl Gel Using Low Frequency Ultrasound of 500kHz

500KHz 초음파를 이용한 Lidocaine HCl Gel의 경피투과 효과

  • Jeong, Dae-In (Department of Physical Therapy, Graduate School, Dongshin University) ;
  • Yoon, Se-Won (Department of Physical Therapy, Graduate School, Dongshin University) ;
  • Choi, Sug-Ju (Department of Physical Therapy, Graduate School, Dongshin University) ;
  • Lee, Jeong-Woo (Department of Physical Therapy, Graduate School, Dongshin University) ;
  • Kim, Myong-Hoon (Department of Physical Therapy, Kwangju Health College) ;
  • Kim, Tae-Youl (Department of Physical Therapy, Dongshin University)
  • 정대인 (동신대학교 대학원 물리치료학과) ;
  • 윤세원 (동신대학교 대학원 물리치료학과) ;
  • 최석주 (동신대학교 대학원 물리치료학과) ;
  • 이정우 (동신대학교 대학원 물리치료학과) ;
  • 김명훈 (광주보건대학 물리치료과) ;
  • 김태열 (동신대학교 물리치료과)
  • Published : 2006.02.24
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Abstract

Purpose: This study conducted the following experiment to examine transdermal permeation effects or 500 KHz ultrasound with lidocaine HCl. Methods; First, to experiment skin permeation enhancement effects of 500 KHz ultrasound frequency, it produced apparatus and transducer of 500 KHz ultrasound and Franz diffusion cell for skim permenation experiment suitable to purposes of the experiment. Transdermal permeation experiment applied Lidocaine HCL gel to skin of hairless mouse depending on ultrasound frequency and duty cycle and analyzed permeation ratio with HPLC. Results: As a result of fixing lidocaine HCl gel at the same intensity with pulsed mode and continuous mode and comparing transdermal permeation ratio by frequency, transdermal permeation ratio was increased at 500 KHz ultrasound and remarkably increased at continuous ultrasound. It was found that 1 MHz and 500 KHz ultrasound in transdermal permeation experiment enhanced transdermal permeation of lidocaine HCl. In particular, transdermal permeation of 500 KHz using lidocaine HCl gel was highest. Conclusion: However, researches considering various frequencies, intensities and application hours in low frequency areas including 500 KHz ultrasound are needed to increase deep permeation or drugs.

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