Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Intestinal Lymphangiectasia in a Yorkshire terrier Dog: Clinical Outcome, Clinicopathological and Histopathological Findings

요크셔테리어견에서 발생한 Intestinal Lymphangiectasia: 임상적 결과와 임상병리학적, 조직병리학적 소견

  • Hwang Du-Na (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Park Chul (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Kang Byeong-Teck (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Jeong Soon-Wuk (Department of veterinary surgery, College of veterinary medicine, Konkuk University) ;
  • Sur Jung-Hyang (Department of veterinary pathology, College of veterinary medicine, Konkuk University) ;
  • Park Hee-Myung (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
  • 황두나 (건국대학교 수의과대학 수의내과학교실) ;
  • 박철 (건국대학교 수의과대학 수의내과학교실) ;
  • 강병택 (건국대학교 수의과대학 수의내과학교실) ;
  • 정순욱 (건국대학교 수의과대학 수의외과학교실) ;
  • 서정향 (건국대학교 수의과대학 수의병리학교실) ;
  • 박희명 (건국대학교 수의과대학 수의내과학교실)
  • Published : 2006.06.01
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Abstract

A 7-year-old, 3.16 kg intact male Yorkshire terrier had the history of abdominal distension, diarrhea, and weight loss. On the basis of history takings, physical examination, laboratory tests, radiography, ultrasonography, exploratory laparotomy, and histopathological examination, the dog was diagnosed definitely as intestinal lymphangiectasia. In this case, signs and results are consistent with those of other reports, but some clinicopathological findings such as hypocalcemia and hypocholesterolemia are not. This means that the findings were not completely in accord with the typical ones of intestinal lymphangiectasia in this dog. Prednisolone was prescribed to treat. However, it was not effective sufficiently. Thus, azathioprine was added to the regimen used in the first trial, and it was quite efficient in inducing remission in intestinal lymphangiectasia. The clinical signs were improved to the combined therapy. This case report demonstrates that the combined therapy for intestinal lymphangiectasia can be used as an alternative to only glucocorticoid therapy.

3.16 kg의 몸무게를 가진, 7년령의 거세하지 않은 수컷 요크셔테리어견이 복부팽만, 설사, 체중감소로 내원하였다. 병력청취, 신체검사, 실험실검사, 방사선학적 검사, 초음파검사, 탐색적 개복술과 조직병리학적 검사 둥을 통해 최종적으로 intestinal lymphangiectasia로 진단되었다. 본 증례에서 나타난 증상과 여러 검사 결과들은 이전에 보고된 증상 및 결과와 대체로 일치하였으나, 저칼슘혈증과 저콜레스테롤혈증을 나타내지 않았다는 점에서 기존의 증례와 차이가 있었다. 처치법으로 프레드니솔론 (Prednisolone $Korns^(R)$, 한국 코러스, 충북, 한국, 2 mg/kg. 경구투여, 1일 2회)을 사용하였지만 효과가 없었다. 따라서, 아자싸이어프린 ($Azaprine^(R)$, 한국 유나이티드 제약, 충남, 한국, 1 mg/kg, 경구투 여, 1일 l회)을 추가하여 복용시킨 결과 임상증상이 개선되었다.

Keywords

References

  1. Arnaud L, Bruno D. Ultrasonographic diagnosis - small bowel lymphangiectasia in a dog. Vet Radiol Ultrasound 2004; 6: 565-567
  2. Ayako H, Tatsuro K, Tsutomu K, Norio T, Akira T, Tadashi M, Tetsuo M, Hiroyuki M. Protein-losing enteropathy complicated with recurrent convulsions and developmental delay in a 4-month-old boy. Pediatric international 2002; 44: 686-689 https://doi.org/10.1046/j.1442-200X.2002.01624.x
  3. Barabino A, Torrente F, Ventura A, Cucchiaras S, Castro M, Barbera C. Azathioprine in paediatric inflammatory bowel disease: an Italian multi centre survey. Aliment Pharmacol Ther 2002; 16: 1125-1130 https://doi.org/10.1046/j.1365-2036.2002.01269.x
  4. Cheung TK. Florin THJ. 6-thioguanine: a new old drug to procure remission in inflammatory bowel disease. Intern Med J 2003; 33: 44-46 https://doi.org/10.1046/j.1445-5994.2003.00321.x
  5. Cornelia MG, Gerhard R, Volker G, Michael G, Nicole B, Tilo A, Jurgen S. Prior bowel resections, perianal disease, and a high initial Crohn's disease activity index are associated with corticosteroid resistance in active Crohn's disease. The American journal of gastroenterology 2002; 97: 1438-1445 https://doi.org/10.1111/j.1572-0241.2002.05685.x
  6. Ettinger SJ, Feldman EC. Diseases of the small intestine. In: Textbook of veterinary internal medicine. 6th ed. St. Louis: Elsevier Saunders. 2000: 1373-1375
  7. Kull PA, Hess RS, Craig LE, Saunders HM, Washabau RJ. Clinical, clinicopathologic, radiologic, and ultrasonographic characteristics of intestinal lymphangiectasia in dogs: 17 cases (1996-1998). J Am Vet Med Assoc 2001; 219: 197-202 https://doi.org/10.2460/javma.2001.219.197
  8. Martha LM, David SB, Laura JA. Ultrasonographic appearance and etiology of corrugated small intestine. Vet Radiol Ultrasound 2003; 44: 199-203 https://doi.org/10.1111/j.1740-8261.2003.tb01271.x
  9. Paoluza OA, Pica R, Marcheggiano A, Crispino P, Iacopini F, Iannoni C, Rivera M, Paoluzi P. Azathioprine or methotrexate in the treatment of patients with steroid-dependent or steroid-resistant ulcerative colitis: results of an open-label study on efficacy and tolerability in inducing and maintaining remission. Aliment Pharmacol Ther 2002; 16: 1751-1759 https://doi.org/10.1046/j.1365-2036.2002.01340.x
  10. Rutgeerts PJ. Review article: the limitations of corticosteroid therapy in Crohn's disease. Aliment Pharmacol Ther 2001; 15: 1515-1525 https://doi.org/10.1046/j.1365-2036.2001.01060.x
  11. Suter MM, Palmer DG, Schenk H. Primary intestinal lymphangiectasia in three dogs: A morphological and immunopathological investigation. Vet Pathol 1985; 22: 123-130 https://doi.org/10.1177/030098588502200205
  12. Thomas GN, John SM. Gastrointestinal tract. In: Small animal diagnostic ultrasound. 2nd ed. Philadelphia: W.B. Saunders company. 2002: 208-212
  13. Timothy HF. Resistance to glucocorticosteroid therapy in inflammatory bowel disease. Journal of Gastroenterology and Hepatology 2003; 18: 613-615 https://doi.org/10.1046/j.1440-1746.2003.03054.x
  14. Watson PJ. Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dog. J Small Anim Pract 2003; 44: 306-312 https://doi.org/10.1111/j.1748-5827.2003.tb00159.x
  15. Williams DA, Guilford WG, Center SA, Strombeck DR, Meyer DJ. Malab-sorption, small intestinal bacterial overgrowth, and protein-losing enteropathy. In: Strombeck's Small Animal Gastroenterology. 3rd ed. Philadelphia: W. B. Saunders. 1996: 375-378