Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Muscle tissue Distribution Level of Ampicillin in Olive flounder(Paralichthys olivaceus), Rockfish(Sebastes schlegeli), and Red sea bream(Pagrus major) following oral administration

Ampicillin의 경구투여에 따른 양식 어류(넙치, 조피볼락, 참돔)의 근육조직내 잔류량의 변화

  • Cho Yoon-Hee (College of Veterinary Medicine, Chonbuk National University) ;
  • Jung Won-Chul (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Shin Yong-Woon (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim Kyoung-Won (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Ha Ji-Young (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Heo Sung-Hyek (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim Eui-Gyung (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Chung Hee-Sik (Livestock Division, Gyeongnam Provincial Government) ;
  • Kang Seok-Joong (Division of Marine Bioscience, Gyeongsang National University) ;
  • Choi Yu-Jeong (Gyeongsangnam-do Livestock Promotion Institute) ;
  • Kim Suk (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee Hu-Jang (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • 조윤희 (전북대학교 수의과대학) ;
  • 정원철 (경상대학교 수의과대학 동물의학연구소) ;
  • 신용운 (경상대학교 수의과대학 동물의학연구소) ;
  • 김경원 (경상대학교 수의과대학 동물의학연구소) ;
  • 하지영 (경상대학교 수의과대학 동물의학연구소) ;
  • 허성혁 (경상대학교 수의과대학 동물의학연구소) ;
  • 김의경 (경상대학교 수의과대학 동물의학연구소) ;
  • 정희식 (경상남도 축산과) ;
  • 강석중 (경상대학교 해양생물이용학부) ;
  • 최유정 (경상남도 축산진흥연구소) ;
  • 김석 (경상대학교 수의과대학 동물의학연구소) ;
  • 이후장 (경상대학교 수의과대학 동물의학연구소)
  • Published : 2006.06.01
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Abstract

The residue depletion of ampicillin was investigated in the olive flounder (Paralichthys olivaceus), rockfish (Sebastes schlegeli), and red sea bream (Pagrus major) after 5 days treatment with medicated feed at a dose of 100 mg/kg bw/day. Fishes were sampled for muscle on 1st, 2nd, 3rd, and 4th day after treatment. Ampicillin concentrations were determined by high performance liquid chromatography after SPE column extraction. The recovery rates of ampicillin in muscle samples ranged 94-98% and 83-88% for the concentration of 0.05 mg/kg and 0.1 mg/kg, respectively. Ampicillin concentrations detected on 1st day after treatment were 0.143, 0.138, and 0.187 mg/kg in the muscle of olive flounder, rockfish, and red sea bream, respectively. After a withdrawal of 3 days, muscle concentrations were 0.016, 0.012, and 0.021 mg/kg in the olive flounder, rockfish, and red sea bream, respectively. Ampicillin was not detectable in muscle samples on 4 days following withdrawal of the medicated feed. From results of the present study, a withdrawal period of ampicillin is proposed on 5 days after 5 days treatment with medicated feed at a dose of 100 mg/kg bw/day to avoid the presence of excessive residues of the edible muscles of olive flounder, rockfish, and red sea bream.

Keywords

References

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