비글견의 간 CT 혈관조영상에서의 Iopamidol과 Iopromide, Iohexol 조명제의 비교실험

A Comparison of Iopamidol with Iopromide and Iohexol Contrast Media in Hepatic CT Angiography in Beagle Dogs

  • 정유철 (서울대학교 수의과대학 수의학과) ;
  • 임창윤 (서울대학교 수의과대학 수의학과) ;
  • 김경민 (서울대학교 수의과대학 수의학과) ;
  • 이성옥 (서울대학교 수의과대학 수의학과) ;
  • 정주현 (서울대학교 수의과대학 수의학과) ;
  • 장진화 (서울대학교 수의과대학 수의학과) ;
  • 오선경 (서울대학교 수의과대학 수의학과) ;
  • 송경진 (서울대학교 수의과대학 수의학과) ;
  • 윤정희 (서울대학교 수의과대학 수의학과) ;
  • 최민철 (서울대학교 수의과대학 수의학과)
  • Jeong Yu-Cheol (College of Veterinary Medicine, Seoul National University) ;
  • Lim Chang-Yun (College of Veterinary Medicine, Seoul National University) ;
  • Kim Gyeong-Min (College of Veterinary Medicine, Seoul National University) ;
  • Lee Sung-Ok (College of Veterinary Medicine, Seoul National University) ;
  • Jung Joo-Hyun (College of Veterinary Medicine, Seoul National University) ;
  • Chang Jin-Hwa (College of Veterinary Medicine, Seoul National University) ;
  • Oh Sun-Kyoung (College of Veterinary Medicine, Seoul National University) ;
  • Song Kyoung-Jin (College of Veterinary Medicine, Seoul National University) ;
  • Yoon Jung-Hee (College of Veterinary Medicine, Seoul National University) ;
  • Choi Min-Cheol (College of Veterinary Medicine, Seoul National University)
  • 발행 : 2006.06.01

초록

The purpose of this paper was to compare the clinical efficacy of iopamidol and iopromide, iohexol nonionic contrast media in terms of their image quality in Beagle dogs with hepatic CT angiography and their application in veterinary clinics. With 9 Beagle dogs, contrast media of iopamidol (pamiray-$300^(R)$) and iopromide (ultravist-$300^(R)$, iohexol (omnipaque-$300^(R)$) were induced intravenously (600 mg I/kg, BW) and CT angiography was done under general anesthesia. CT scan included scout, pre-contrast and cine examinations. During CT angiography, peak HU (Hounsfield unit) and peak time were examined on each site (ROI; region of interest) of the aorta, caudal vena cava, potral vein and liver parenchyma. Any side effects were also examined. After experiments, it was found that there were no significant changes of HU and maximal enhancing time of each ROIs of aorta, caudal vena cava, portal vein and liver parenchyma between these contrast media. And any side effects were not noted. So it is concluded that iopamidol has similiar contrast enhancement like as iopromide and iohexol in hepatic angiography and and it is thought to be useful for evaluation of the abdominal organs by CT scan in veterinary clinics.

키워드

참고문헌

  1. Choi YH, Chung JW, Choi GM, Yoon CJ, Kim KH, Moon SG, Kim HC, Park JH. Paired comparison of iopamidol and iopromide in hepatic arteriography. J Korean Radiol Soc 2003; 48: 141-145 https://doi.org/10.3348/jkrs.2003.48.2.141
  2. Dyet JF, Carter EC, Hartley WC. Comparision of iopromide and iopamidol in left ventricular angiography and in coronary angiography. British J Radiol 1990; 63: 700-705 https://doi.org/10.1259/0007-1285-63-753-700
  3. Fattori R, Piva R, Schicchi F, Pancrazi A, Gabrielli G, Marzocchi A, Piovaccari G, Blandini A, Magnani B. Iomeprol and iopamidol in cardiac angiography: a randomized, double-blind, parallel-group comparison. Eur J Radiol 1994; 18 Suppl 1: S61-S66 https://doi.org/10.1016/0720-048X(94)90369-7
  4. Goldberg SN, Abrahams J, Drayer BP, Goldring S, Bernarding M, Brunetti J. A comparison of iopromide with iopamidol and iohexol for contrast-enhanced computed tomography. Invest Radiol 1994; Suppl 1: S76-83
  5. Holland M. Contrast agents. Vet Clinic North Am Small Anim Pract 1993; 23: 269-279 https://doi.org/10.1016/S0195-5616(93)50028-1
  6. Katayama H, Yamaguchi K, Kozuka T, Takshima T, Seez P, Matsuura K. Adverse reactions to ionic and nonionic contrast media. A report from the Japanese committee on the Safety of Contrast Media. Radiology 1990; 175: 621-628 https://doi.org/10.1148/radiology.175.3.2343107
  7. Lavin LM. Radiography in veterinary technology, 3rd ed. Philadelphia, Saunders. 2003: 237-238
  8. Morris TW. Ventricular fibrillation during right coronary arteriography with ioxaglate, iohexol and iopamidol in dogs. Invest Radiol 1988; 23(3): 205-208 https://doi.org/10.1097/00004424-198803000-00009
  9. Ownes JM, Biery DN. Radiographic interpretation for the small animal clinician. 2nd ed. Baltimore, Williams & Wilins. 1999: 15-16
  10. Renwick IGH , Fowler RC. A double-blind comparison of iopromide and iopamidol in intrvenous urography. Clin Radiol 1990; 41(6): 405-407 https://doi.org/10.1016/S0009-9260(05)80601-4
  11. Verow P, Nossen JO, Sheppick A, Kjaersgaard P. A comparison of iodixanol with iopmidol in aorto-femoral angiography. Br. J. Radiolo 1995; 68: 973-978 https://doi.org/10.1259/0007-1285-68-813-973
  12. Wisneski JA, Gertz EW, Adhlgren M, Muslin A. Comparison of low osmolarity ionic(iosaglate) versus nonionic (iopamidol) contrast media in cardiac angiography. Am J Cardiol 1989; 63: 489-495 https://doi.org/10.1016/0002-9149(89)90325-1
  13. 임근여, 구진모, 김승호, 김지훈. 복부 CT에서 비이온성 경정맥조영제의 임상평가. 대한방사선의학회지 2003; 49: 197-201