대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제27권3호
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- Pages.725-736
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- 2006
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- 1226-9174(pISSN)
Human Neuroblastoma Cell Line BE2에 대한 건비보신항암탕(健脾補腎抗癌湯)의 세포고사 기전 연구
Study of The Apoptotic Mechanisms of Gunbibosinhangam-tang on Human Neuroblastoma Cell Line BE2
- 조영기 (원광대학교 한의과대학 전주한방병원) ;
- 문미현 (원광대학교 한의과대학 전주한방병원) ;
- 이성균 (원광대학교 한의과대학 전주한방병원) ;
- 정현애 (원광대학교 한의과대학 익산한방병원) ;
- 이정섭 (원광대학교 한의과대학 전주한방병원) ;
- 남상규 (원광대학교 한의과대학 전주한방병원) ;
- 문구 (원광대학교 한의과대학 전주한방병원) ;
- 신선호 (원광대학교 한의과대학 전주한방병원) ;
- 김동웅 (서울 광동한방병원)
- Cho, Young-Kee (Wonkwang University Jeonju Oriental Medicine Hospital) ;
- Moon, Mi-Hyun (Wonkwang University Jeonju Oriental Medicine Hospital) ;
- Lee, Seong-Kyun (Wonkwang University Jeonju Oriental Medicine Hospital) ;
- Jeong, Hyun-Ae (Wonkwang University Iksan Oriental Medicine Hospital) ;
- Lee, Jung-Sub (Wonkwang University Jeonju Oriental Medicine Hospital) ;
- Nam, Sang-Kyu (Wonkwang University Jeonju Oriental Medicine Hospital) ;
- Moon, Goo (Wonkwang University Jeonju Oriental Medicine Hospital) ;
- Shin, Sun-Ho (Wonkwang University Jeonju Oriental Medicine Hospital) ;
- Kim, Dong-Woung (Kwangdong Oriental Medicine Hospital)
- 발행 : 2006.09.30
초록
Objective: In order to investigate cell death mechanisms by Gunbibosinhangam-Tang(G.B.H) in cancer cells, the activities of apoptosis signaling pathway were tested in human neuroblastoma cell line BE2. Methods: Viability of BE2 cells was markedly decreased by treatment of the water extract of G.B.H in a dose-dependent manner. G.B.H-induced cell death was confirmed as apoptosis characterized by chromatin condensation, We tested whether the water extract of G.B.H affects the anti-apoptotic proteins such as Bcl-