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남해안 양식어류의 fluoroquinolone계 항균제 잔류량

Residual Concentrations of Fluoroquinolones in Farmed Fish in the Southern Coast of Korea

  • 김풍호 (국립수산과학원 식품위생팀) ;
  • 이희정 (국립수산과학원 식품위생팀) ;
  • 조미라 (국립수산과학원 식품위생팀) ;
  • 이태식 (국립수산과학원 식품위생팀) ;
  • 하진환 (제주대학교 식품공학과)
  • Kim Poong-Ho (Food Sanitation Research Team, National Fisheries Research and Development Institute) ;
  • Lee Hee-Jung (Food Sanitation Research Team, National Fisheries Research and Development Institute) ;
  • Jo Mi-Ra (Food Sanitation Research Team, National Fisheries Research and Development Institute) ;
  • Lee Tae-Seek (Food Sanitation Research Team, National Fisheries Research and Development Institute) ;
  • Ha Jin-Hwan (Department of Food Science and Engineering, Cheju National University)
  • 발행 : 2006.04.01

초록

Fluoroquinoles have a wide range of antimicrobial properties and are effective in the treatment of bacterial diseases in fish. The use of fluoroquinoles continues to grow steadily. Fluoroquinolone antibiotics are probably the most important class used among synthetic antibiotics in human and veterinary medicines because of their broad activity spectrum and good oral absorption. This study was conducted to estimate the residue of antibiotics in four species of farmed fishes, including olive flounder (Paralichthys olivaceus), black rock fish (Sebastes schlegeli), red sea bream (Pagrus major), and sea bass (Lateolabrax japonicus), collected from fish farms located in the southern coastal area of Korea. The residues of fluoroquinolones were determined using high performance liquid chromatography (HPLC) with a fluorescence detector. Residuals of five fluoroquinolones in muscle tissue of farmed fish were analyzed. We found that enrofloxacin was the most common agent in fish muscle, and that ciprofloxacin was the next most common. The range of detected concentrations of fluoroquinolones in olive flounder muscle was 0-0.859 mg/kg in 32.6% of all samples. Enrofloxacin was commonly detected in sea bass muscle at a range of 0-0.143 mg/kg in 38.9% of all samples. Fluoroquinolones were detected in 6.9% of black rock fish muscle and in 16.6% of sea bream, although the detected concentration was below 0.01 mg/kg. The maximum detection value of enrofloxacin and ofloxacin in olive flounder at the time of shipping was 0.102 mg/kg and 0.09 mg/kg, respectively; no other antimicrobials were detected. We detected no antimicrobial substances in red sea bream.

키워드

참고문헌

  1. EMEA. 2002. Enrofloxacin summary report (5). Committee for Veterinary Medical Products. The European Agency for the Evaluation of Medicinal Products. EMEA/MRL/820/02- FINAL
  2. Reo, G.J. and J.H. Kim. 1994. A study on efficacy and safety of antibacterial (pefloxacine methanesulfonate) to cultured fish, Cyprinus caprio and Paralichths olivaceus. Kor. J. Vet. Res., 34, 153-1994
  3. Reo, G.J., S.C. Park and D.W. Kim. 1998. A study on efficacy and safety of quinolone antibacterial (ciprofloxacin) to bacterial diseases in cultured fish, Cyprinus caprio and Onchrohynchus mykiss. Kor. J. Vet. Publ. Hlth., 22, 175-186
  4. Herikstad, H., P. Hayers, M. Mokhtar, M.L. Fracaro, E.J. Threlfall and F.J. Angulo. 1997. Emerging quinoloneresistant Salmonella in the United States. Emerg. Infect. Dis., 3, 371-372 https://doi.org/10.3201/eid0303.970316
  5. Horie, M., H. Saito, N. Nose and H. Nakazawa. 1995. Simultaneous determination of eight quinolone antibacterials in meat and fish by high performance liquid chromatography. J. Food Hyg. Soc. Japan, 36, 62-67 https://doi.org/10.3358/shokueishi.36.62
  6. KAHPA (Korea Animal Health Products Association). 2001. The Guidebook of Veterinary Antibiotics, Kyungsung Munhwasa, Gyeonggi-do, 655-732
  7. Koga, H., A. Itoh, S. Murayama, S. Suzue and T. Irikura. 1980. Structure-activity relationships of antibacterial 6,7 - and 7,8-disubstituted 1-alky1-1,4-dihydro-4oxoquino1ine-3-carboxylic acids. J. Med. Chem., 23, 1358-1363 https://doi.org/10.1021/jm00175a001
  8. Markwardt, M.N. and G.W. Klontz. 1998. A method to eliminate the symptomatic carrier state of Aeromonas salmonicida in salmonids. J. Fish Dis., 12, 317
  9. Morales-Munoz, S., J.L. Luque-Garcia and M.D. Luque de Castro. 2004. Continuous microwave-assisted extraction coupled with derivatization and fluorimetric monitoring for the determination of fluoroquinolone antibacterial agents from soil samples. J. Chromatogr. A, 1059, 25-31 https://doi.org/10.1016/j.chroma.2004.09.086
  10. Nakano, S., T. Aoki and T. Kitao. 1989. In vitro antimicrobial activity of pyridonecarboxylic acids against fish pathogens. J. Aquat. Anim. Health, 1, 43 https://doi.org/10.1577/1548-8667(1989)001<0043:IVAAOP>2.3.CO;2
  11. Son, S.W. 1999. Studies on the detection of quinolones in foods of animal origin. Ph.D. Thesis, Seoul National University, 1-120
  12. Yun, S.M., C.M. Lim, B.H. Cho, M.L. Keom, M.B. Kim and S.W. Son. 2003. Development of multi-residue high-performance liquid chromatography for the determination of fluroquinolones in eggs. Kor. J. Vet. Publ. Hlth, 27, 177-182

피인용 문헌

  1. Residues of Antibiotics in Wild and Cultured Fishes Collected from Coast of Korea vol.43, pp.1, 2010, https://doi.org/10.5657/kfas.2010.43.1.012
  2. Processing optimization of restructured jerky from sea rainbow trout frame muscle vol.25, pp.3, 2016, https://doi.org/10.1007/s10068-016-0123-6
  3. Alcohol Metabolizing Activity of Fermented Sea Tangle Juice vol.43, pp.1, 2010, https://doi.org/10.5657/kfas.2010.43.1.001