A Case of Monophasic Fibrous Synovial Sarcoma Confirmed Primary Pulmonary Origin by 18F-FDG PET/CT

PET/CT로 폐에서 기원한 것을 확인한 원발성 단상성 섬유성 활막육종 1예

  • Lee, Eun A (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Lee, Do Young (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kwag, Hyon Joo (Department of Radiology, Kangbuk Samsung Hospital) ;
  • Kim, Min Kyung (Department of Pathology, Kangbuk Samsung Hospital) ;
  • Oh, Tae Yun (Department of Thoracic Surgery, Kangbuk Samsung Hospital) ;
  • Lim, Si Young (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Lim, Seong Yong (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
  • 이은아 (성균관대학교 의과대학 내과학교실, 강북삼성병원 호흡기내과) ;
  • 이도영 (성균관대학교 의과대학 내과학교실, 강북삼성병원 호흡기내과) ;
  • 곽현주 (강북삼성병원 영상의학과) ;
  • 김민경 (강북삼성병원 병리과) ;
  • 오태윤 (강북삼성병원 흉부외과) ;
  • 임시영 (성균관대학교 의과대학 내과학교실, 강북삼성병원 호흡기내과) ;
  • 임성용 (성균관대학교 의과대학 내과학교실, 강북삼성병원 호흡기내과)
  • Received : 2006.04.18
  • Accepted : 2006.06.07
  • Published : 2006.06.30

Abstract

Most malignant mesenchymal tumors of the lung are metastases of a primary tumor from elsewhere in the body. A primary pulmonary synovial sarcoma is a very rare neoplasm that accounts for approximately 10% of soft tissue sarcomas and makes up only 0.5% of all primary lung malignancies. We report a case of a primary pulmonary synovial sarcoma in a 60-year old woman. In this case, a lung metastasis was excluded using 18F-FDG PET /CT imaging.

저자들은 60세 여자환자에서 18F-FDG PET/CT를 사용하여 폐에서 원발한 것을 확인하고 조직학적 및 면역 조직 화학 염색상 단상성 섬유성 형태를 가진 원발성 폐활막 육종 1예를 경험하였기에 이를 문헌 고찰과 함께 보호하는 바이다.

Keywords

References

  1. Hosono T, Hironaka M, Kobayashi A, Yamasawa H, Bando M, Ohno S, et al. Primary pulmonary synovial sarcoma confirmed by molecular detection of SYTSSX1 fusion gene transcripts: a case report and review of the literature. Jpn J Clin Oncol 2005;35:274-9 https://doi.org/10.1093/jjco/hyi073
  2. Hisaoka M, Hashimoto H, Iwamasa T, Ishikawa K, Aoki T. Primary synovial sarcoma of the lung: report of two cases confirmed by molecular detection of SYT-SSX fusion gene transcripts. Histopathology 1999;34:205-10 https://doi.org/10.1046/j.1365-2559.1999.00630.x
  3. Niwa H, Masuda S, Kobayashi C, Oda Y. Pulmonary synovial sarcoma with polypoid endobronchial growth: a case report, immunohistochemical and cytogenetic study. Pathol Int 2004;54:611-5 https://doi.org/10.1111/j.1440-1827.2004.01670.x
  4. Okamoto S, Hisaoka M, Daa T, Hatakeyama K, Iwamasa T, Hashimoto H. Primary pulmonary synovial sarcoma: a clinicopathologic, immunohistochemical, and molecular study of 11 cases. Hum Pathol 2004;35:850-6 https://doi.org/10.1016/j.humpath.2004.02.011
  5. Chan JA, McMenamin ME, Fletcher CD. Synovial sarcoma in older patients: clinicopathological analysis of 32 cases with emphasis on unusual histological features. Histopathology 2003;43:72-83 https://doi.org/10.1046/j.1365-2559.2003.01643.x
  6. Zeren H, Moran CA, Suster S, Fishback NF, Koss MN. Primary pulmonary sarcomas with features of monophasic synovial sarcoma: a clinicopathological, immunohisto-chemical, and ultrastructural study of 25 cases. Hum Pathol 1995;26:474-80 https://doi.org/10.1016/0046-8177(95)90242-2
  7. Duran-Mendicuti A, Costello P, Vargas SO. Primary synovial sarcoma of the chest: radiographic and clinicopathologic correlation. J Thorac Imaging 2003;18:87-93 https://doi.org/10.1097/00005382-200304000-00006
  8. Yoon GS, Park SY, Kang GH, Kim OJ. Primary pulmonary sarcoma with morphologic features of biphasic synovial sarcoma: a case report. J Korean Med Sci 1998;13:71-6 https://doi.org/10.3346/jkms.1998.13.1.71
  9. Song SH, Lee KH, Oh JH, Moon HS, Song JS, Park SH, et al. A case of primary pulmonary sarcoma with morphologic features of biphasic synovial sarcoma. Tuberc Respir Dis 1998;45:1284-89 https://doi.org/10.4046/trd.1998.45.6.1284
  10. Dennison S, Weppler E, Giacoppe G. Primary pulmonary synovial sarcoma: a case report and review of current diagnostic and therapeutic standards. Oncologist 2004;9:339-42 https://doi.org/10.1634/theoncologist.9-3-339
  11. Kawai A, Woodruff J, Healey JH, Brennan MF, Antonescu CR, Ladanyi M. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med 1998;338:153-60 https://doi.org/10.1056/NEJM199801153380303
  12. Spillane AJ, A'Hern R, Judson IR, Fisher C, Thomas JM. Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J Clin Oncol 2000;18:3794-803 https://doi.org/10.1200/JCO.2000.18.22.3794