Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Respiratory Review of 2006 -Asthma-

호흡기 내과 의사를 위한 Respiratory Review of 2006 -Asthma-

  • Lee, Ka Young (Department of Internal Medicine, Airway Remodeling Laboratory, Chonbuk National University Medical School) ;
  • Lee, Yong Chul (Department of Internal Medicine, Airway Remodeling Laboratory, Chonbuk National University Medical School)
  • 이가영 (전북대학교 의과대학 내과학 교실, 기도 개형 연구실) ;
  • 이용철 (전북대학교 의과대학 내과학 교실, 기도 개형 연구실)
  • Published : 2006.08.30
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Abstract

Keywords

References

  1. American Thoracic Society. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000;162:2341-51
  2. Bradding P, Roberts JA, Britten KM, Montefort S, Diukanovic R, Mueller R, et al. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways evidence for the human mast cell as a source of these cytokines, Am J Respir Cell Mol BioI 1994; 10:471-80 https://doi.org/10.1165/ajrcmb.10.5.8179909
  3. Broide DH, Lotz M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 1992;89:958-67 https://doi.org/10.1016/0091-6749(92)90218-Q
  4. Thomas PS, Yates DH, Barnes PI Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. Am J Respir Crit Care Med 1995; 152:76-80 https://doi.org/10.1164/ajrccm.152.1.7599866
  5. Berry MA, Hargadon B, Shelley M, Parker D, Shaw DE, Green RH, et al. Evidence of a role of tumor necrosis factor $\alpha$ in refractory asthma. N Engl J Med 2006;354:697-708 https://doi.org/10.1056/NEJMoa050580
  6. Ohkawara Y, Yamauchi K, Tarmo Y, Tamura G, Ohtani H, Nagura H, et al. Human lung mast cells and pulmonary macrophages produce tumor necrosis factor-alpha in sensitized lung tissue after IgE receptor triggering. Am J Respir Cell Mol BioI 1992;7:385-92 https://doi.org/10.1165/ajrcmb/7.4.385
  7. Howarth PH, Babu KS, Arshad HS, Lau L, Buckley M, McConnell W. et al. Turner necrosis factcr (TNF- $\alpha$) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax 2005;60:1012-8 https://doi.org/10.1136/thx.2005.045260
  8. Erzurum SC. Inhibition of tumor necrosis factor$\alpha$ for refractory asthma. N Engl J Med 2006;354:754-8 https://doi.org/10.1056/NEJMe058266
  9. Choi IW, Kim YS, Kim DK, Choi JH, Seo KH, Im SY, et al. Platelet-activating factor-mediated NF- $\kappa$B dependency of a late anaphylactic reaction. J Exp Med 2003;198: 145-51 https://doi.org/10.1084/jem.20022129
  10. Choi IW, Kim S, Kim YS, Ko HM, 1m SY, Kim JH, et al. TNF- $\alpha$ induces the late-phase airway hyperresponsiveness and airway inflannnation through cytosolic phsopholipase A(2) activation. J Allergy Clin Immunol 2005; 116:537 -43 https://doi.org/10.1016/j.jaci.2005.05.034
  11. Akdis M, Blaser K, Akdis CA. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention. and treatment of allergic disease. J Allergy Clin Immunol 2005; 116:961-8 https://doi.org/10.1016/j.jaci.2005.09.004
  12. Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, et al. Reversing the defective induction of IL-lO-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 2006; 116:146-55 https://doi.org/10.1172/JCI21759
  13. HawrylowiczC, Richards D, Loke TK, Corrigan C, Lee T. A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients. J Allergy Clin Immunol 2002; 109:369-70 https://doi.org/10.1067/mai.2002.121455
  14. John M, Lim S, Seybold J, Jose P, Robichaud A, O'Connor B, et al. Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflannnatory protein-lalpha, granulocyte-macrophage colony-stirnulating factor, and interferon-gannna release from alveolar macrophages in asthma. Am J Respir Crit Care Med 1998; 157:256-62 https://doi.org/10.1164/ajrccm.157.1.9703079
  15. Homer RJ, Elias JA. Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology 2005;20:28-35 https://doi.org/10.1152/physiol.00035.2004
  16. Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeablity, and angiogenesis. Am J Pathol 1995;146:1029-39
  17. Lee YC, Lee HK. Vascular endothelial growth factor in patients with acute asthma. J Allergy Clin Immunol 2001;107:1106 https://doi.org/10.1067/mai.2001.115628
  18. Hoshino M, Nakamura Y, Hamid QA. Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma. J Allergy Clin Immunol 2001;107:1034-8 https://doi.org/10.1067/mai.2001.115626
  19. Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin Immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 2001;107:295-301 https://doi.org/10.1067/mai.2001.111928
  20. Lee YC, Kwak YG, Song CH. Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflannnation in a murine model of toluene diisocyanate-vinduced asthma. J Immunol 2002;168:3595-600 https://doi.org/10.4049/jimmunol.168.7.3595
  21. Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, et al. Vascular endothelial growth factor (VEGF) induces remodeling and enbances Th2meidated sensitization and inflannnation in the lung. Nat Med 2004;10:1095-103 https://doi.org/10.1038/nm1105
  22. Chetta A, Zanini A, Foresi A, D'Ippolito R, TIpa A, Castagnaro A, et al. Vascular endothelial growth factor up-regulation and bronchial wall remodeling in asthma. Clin Exp Allergy 2005;35:1437-42 https://doi.org/10.1111/j.1365-2222.2005.02360.x
  23. Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, et al. Interluekin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor $\beta$ 1. J Exp Med 2001; 194:809-21 https://doi.org/10.1084/jem.194.6.809
  24. Karagiannidis C, Hense G, Martin C, Epstein M, Ruckert B, Mantel PY, et al. Activin A is an acute allergen-responsive cytokine and provides a link to TGF- $\beta$ -mediated airway remodeling in asthma. J Allergy Clin Immunol 2006;117:111-8 https://doi.org/10.1016/j.jaci.2005.09.017
  25. Ezearnuzie CI, Sukurnaran J, Philips E. Effect of wortmannin on humna esoinophil responses in vitro and on bronchial inflanunation and airwa hyperresponsiveness inGuinea pigs in vivo. Am J Respir Crit Care Med 2001;164:1633-9 https://doi.org/10.1164/ajrccm.164.9.2101104
  26. Tigani B, Hannon JP, Mazzoni L, Fozard JR Effects of wortmannin on airways inflanunation induced by allergen in actively sensitised Brown Norway rats. Eur J Pharmacol 2001;433:217-23. https://doi.org/10.1016/S0014-2999(01)01515-1
  27. Kwak YG, Song CH, Yi HK, Hwang PH, Kim JS, Lee KS,et al. Involvement of PTEN in airway hyperresponsiveness and inflanunation in bronchial asthma. J Clin Invest 2003;111:1083-92 https://doi.org/10.1172/JCI16440
  28. Berger J, Moller DE. The mechanisms of action of PPARs. Aunu Rev Med 2002;53:409-35 https://doi.org/10.1146/annurev.med.53.082901.104018
  29. Lee KS, Park SJ, Hwang PH, Yi HK, Song CH, Chai OH,et al. PPAR-ganuna modulates allergic inflanunation through up-regulation of PTEN. FASEB J 2005;19:1033-5 https://doi.org/10.1096/fj.04-3309fje
  30. Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-83 https://doi.org/10.1146/annurev.immunol.14.1.649
  31. Hart LA. Krishnan VL, Adcock IM, Barnes PJ, Chung KF. Activation and localization of transcription factor, nuclear factor-kappa B, in asthma. Am J Respir Crit Care Med 1998;158:1585-92 https://doi.org/10.1164/ajrccm.158.5.9706116
  32. Hobbs K, Negri J, Klinnert M, Rosenwasser L.J, Borish L. Interleukin-10 and transforming growth factor-$\beta$ promoter polyrrrrphisms in allergies and asthma. Am J Respir Crit Care Med 1998;158: 1958-62 https://doi.org/10.1164/ajrccm.158.6.9804011
  33. Takanaski S, Nonaka R, Xing Z, O'Byrne P, Dolovich J, Jordana M Interleukin 10 inhibits lipopolysaccharide- induced survival and cytokine production by human peripheral blood eosinophils, J Exp Med 1994;180:711-5 https://doi.org/10.1084/jem.180.2.711
  34. Kim SR, Lee KS, Park HS, Park SJ, Mn KH, Jin SM, et al. Involvement of IL-10 in peroxisome proliferator-activated receptor ganuna-mediated anti-inflammatory response in asthma. Mol Pharmacol 2005; 68:1568-75
  35. Lee KS, Lee HK, Hayflick JS, Lee YC, Puri KD. Inhibition of phosphoinositide 3-kinase $\delta$ attenuates allergic airway inflanunation and hyperresponsiveness in murine asthma model. FASEB J 2006;20:455-65 https://doi.org/10.1096/fj.05-5045com
  36. van Schalkwyk E, Strydom K, Williams Z, Venter L, Leicht! S, Schrnid-Wrrlitsch C,et al. Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions. J Allergy Clin Immunol 2005;116:292-8 https://doi.org/10.1016/j.jaci.2005.04.023
  37. Lipworth BJ. Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease. Lancet 2005;365:167-75 https://doi.org/10.1016/S0140-6736(05)17708-3