Asian-Australasian Journal of Animal Sciences

  • 제19권11호
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  • Pages.1632-1637
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  • 2006
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Changes in Serum Biochemical Markers of Bone Cell Activity in Growing Thoroughbred Horses

  • Inoue, Yoshinobu (Equine Science Division, Hidaka Training and Research Center, Japan Racing Association) ;
  • Asai, Y. (Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University) ;
  • Ohmori, H. (Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University) ;
  • Fujii, H. (Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University) ;
  • Matsui, T. (Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University) ;
  • Yano, H. (Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University)
  • 투고 : 2006.01.10
  • 심사 : 2006.05.30
  • 발행 : 2006.11.01
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초록

We studied the changes in biochemical markers of bone metabolism in growing Thoroughbred horses. Serum osteocalcin (OC), as a marker for bone formation, and carboxy-terminal propeptide of type-I collagen (PICP), as a marker for bone formation, carboxy-terminal telopeptide of type-I collagen (ICTP), as a marker for bone resorption, were determined in nine clinically healthy horses from 3 d to 17 mo of age. The BW and withers height (WH) increased during the study. On the other hand, a rapid reduction in body weight gain (BWG) was observed between 1 mo and 9 mo of age and a rapid reduction in withers height gain was observed between 1 mo and 5 mo of age. The serum markers decreased significantly with increasing age. In particular, dramatic changes in serum markers occurred between 3 d to 1 wk and 5 to 7 mo of age in these horses, which suggests that bone turnover rapidly decreased after birth. On the other hand, the ratio of PICP to ICTP decreased through the experiment. This result suggests that the reduction in bone formation exceeded that of bone resorption. There was a significant correlation between markers and growth parameters, except for the correlation between PICP and BWG on single linear regression analysis. Serum OC and ICTP were affected by the WH in multiple linear regression analysis. These results indicated that the age-related variation in serum biochemical markers of bone metabolism reflected bone growth, but neither BW nor BWG. Therefore, we consider that changes in bone modeling are the major factor affecting the levels of serum biochemical markers by 17 mo of age in horses.

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참고문헌

  1. Allen, M. J. 2003. Biochemical markers of bone metabolism in animals: uses and limitations. Vet. Clin. Pathol. 32:101-113 https://doi.org/10.1111/j.1939-165X.2003.tb00323.x
  2. Black, A., P. A. Schoknecht, S. L. Ralston and S. A. Shapses. 1999. Diurnal variation and age differences in the biochemical markers of bone turnover in horses. J. Anim. Sci. 77:75-83
  3. Davicco, M. J., Y. Faulconnier, V. Coxam, H. Dubroeucq, W. Martin-Rosset and J. P. Barlet. 1994. Systemic bone growth factors in light breed mares and their foals. Arch. Int. Physiol. Biochim. Biophys. 102:115-119 https://doi.org/10.3109/13813459408996117
  4. Fraher, L. J. 1993. Biochemical markers of bone turnover. Clin.Biochem. 26:431-432 https://doi.org/10.1016/0009-9120(93)80003-D
  5. Hammett, F. S. 1925. A biochemical study of bone growth. I. Changes in the ash, organic matter, and water during growth (Mus Norvegicus Alubinus). J. Biol. Chem. 64:409-428
  6. Hassager, C. and C. Christiansen. Influence of soft tissue body composition on bone mass and metabolism. Bone. 10:415-419 https://doi.org/10.1016/8756-3282(89)90072-0
  7. Hiney, K. 2004. Bone metabolism and activity. In Proceedings of the Texas A&M University conference on equine nutrition research, Collage Station, Texas, pp. 110-122
  8. Kajantie, E., L. Dunkel, J. Risteli, M. Pohjavuori and S. Andersson. 2001. Markers of type I and III collagen turnover as indicators of growth velocity in very low birth weight infants. J. Clin. Endocr. Metab. 86:4299-4306 https://doi.org/10.1210/jc.86.9.4299
  9. Lepage, O. M., M. Marcoux and A. Tremblay. 1990. Serum osteocalcin or bone Gla-protein, a biochemical marker for bone metabolism in horses: differences in serum levels with age. Can. J. Vet. Res. 54:223-226
  10. Lepage, O. M., D. J. Hartmann, R. Eicher, B. Uebelhart, P. Tschudi and D. Uebelhart. 1998. Biochemical markers of bone metabolism in draught and warmblood horses. Vet. J. 156:169-175 https://doi.org/10.1016/S1090-0233(98)80120-2
  11. Lepage, O. M., B. Carstanjen and D. Uebelhart. 2001. Noninvasive assessment of equine bone: an update. Vet. J. 161:10-22 https://doi.org/10.1053/tvjl.2000.0541
  12. Matsui, A., R. Katsuki, H. Fujikawa, M. Kai, K. Kubo, A. Hiraga and Y. Asai. 2004. Effects of uphill exercise on digestible energy intake and energy expenditure during exercise in yearling horses. Asian-Aust. J. Anim. Sci. 17:973-979 https://doi.org/10.5713/ajas.2004.973
  13. Melkko, J., S. Niemi, L. Risteli and J. Risteli. 1990. Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen. Clin. Chem. 36:1328-1332
  14. National Research Council. 1989. Nutrient requirements of horses. 5th Ed. Natinal Academy Press, Washington, DC
  15. Ott, E. A. and J. Kivipelto. 2002. Influence of energy and protein content of the concentrate and restricting concentrate intake on growth and development of weanling horses. The Prof. Anim. Sci. 18:302-311
  16. Parfitt, A. M., L. S. Simon, A. R. Villanueva and S. M. Krane. 1987. Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with Iliac bone formation rates and comparison with total alkaline phosphatase. J. Bone Miner. Res. 2:427-436 https://doi.org/10.1002/jbmr.5650020510
  17. Patterson-Allen, P., C. E. Brautigam, R. E. Grindeland, C. W. Asling and P. X. Callahan. 1982. A specific radioimmunoassay for osteocalcin with advantageous species crossreactivity. Anal. Biochem. 120:1-7 https://doi.org/10.1016/0003-2697(82)90309-8
  18. Price, J. S., B. Jackson, R. Eastell, A. E. Goodship, A. Blumsohn, L. Wright, S. Stoneham, L. E. Lanyon and R. G. Russell. 1995. Age related changes in biochemical markers of bone metabolism in horses. Equine. Vet. J. 27:201-207 https://doi.org/10.1111/j.2042-3306.1995.tb03063.x
  19. Price, J. S. 1998. Biochemical markers of bone metabolism in horses: potentials and limitations? Vet. J. 156:163-165 https://doi.org/10.1016/S1090-0233(98)80117-2
  20. Price, J. S., B. F. Jackson, J. A. Gray, P. A. Harris, L. M. Wright, D. U. Pfeiffer, S. P. Robins, R. Eastell and S. W. Ricketts. 2001. Biochemical markers of bone metabolism in growing thoroughbreds: a longitudinal study. Res. Vet. Sci. 71:37-44 https://doi.org/10.1053/rvsc.2001.0482
  21. Ravn, P., G. Cizza, N. H. Bjarnason, D. Thompson, M. Daley, R. D. Wasnich, M. McClung, D. Hosking, A. J. Yates and C. Christiansen. 1999. Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group. J. Bone Miner. Res. 14:1622-1627 https://doi.org/10.1359/jbmr.1999.14.9.1622
  22. Reller, E., J. Kivipelto and A. Ott. 2003. Age-related changes for serum bone metabolism markers in Thoroughbred and Quarter horse foals. J. Equine Vet. Sci. 23:117-120 https://doi.org/10.1053/jevs.2003.28
  23. Risteli, J., L. Elomaa, S. Niemi, A. Novamo and L. Risteli. 1993. Radioimmunoassay for the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen: a new serum marker of bone collagen degradation. Clin. Chem. 39:635-640
  24. SAS Institute Inc. 1990. SAS User's Guide. SAS Institute Inc., Cary, North Carolina
  25. SAS Institute Inc. 1996. SAS/STAT software: Changes and enhancements through release 6.11. SAS Institute Inc., Cary, North Carolina
  26. Stein, G. S., J. B. Lian and T. A. Owen. 1990. Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J. 4:3111-3123 https://doi.org/10.1096/fasebj.4.13.2210157
  27. Stover, S. M., R. R. Pool, R. B. Martin and J. P. Morgan. 1992. Histological features of the dorsal cortex of the third metacarpal bone mid-diaphysis during postnatal growth in thoroughbred horses. J. Anat. 181(Pt 3):455-69

피인용 문헌

  1. (ORIGINAL) Clinical Usefulness of the Measurement of Bone Mineral Content by Radiographic Absorptiometry in the Young Thoroughbred vol.18, pp.3, 2006, https://doi.org/10.1294/jes.18.99