Annals of Clinical Neurophysiology
- 제8권2호
- /
- Pages.163-170
- /
- 2006
- /
- 2508-691X(pISSN)
- /
- 2508-6960(eISSN)
뇌자도를 이용한 언어 편재화: 예비 연구
Language Lateralization Using Magnetoencephalography (MEG): A Preliminary Study
- 이서영 (강원대학교 신경과) ;
- 강은주 (강원대학교 심리학과) ;
-
김준식
(서울대학교병원 뇌자도 센터) ;
-
이상건
(서울대학교 신경과) ;
-
강혜진
(서울대학교 핵의학과) ;
- 박효진 (서울대학교 핵의학과) ;
-
김성훈
(강원대학교 신경과) ;
- 이승환 (강원대학교 신경과) ;
-
정천기
(서울대학교병원 뇌자도 센터)
- Lee, Seo-Young (Department of Neurology, Kangwon National University) ;
- Kang, Eunjoo (Department of Psychology, Kangwon National University) ;
-
Kim, June Sic
(MEG center, Seoul National University Hospital) ;
-
Lee, Sang-Kun
(Department of Neurology, Seoul National University) ;
-
Kang, Hyejin
(Department of Nuclear Medicine, Seoul National University) ;
- Park, Hyojin (Department of Nuclear Medicine, Seoul National University) ;
-
Kim, Sung Hun
(Department of Neurology, Kangwon National University) ;
- Lee, Seung Hwan (Department of Neurology, Kangwon National University) ;
-
Chung, Chun Kee
(MEG center, Seoul National University Hospital)
- 발행 : 2006.12.30
초록
Backgrounds: MEG can measure the task-specific neurophysiologic activity with good spatial and time resolution. Language lateralization using noninvasive method has been a subject of interest in resective brain surgery. We purposed to develop a paradigm for language lateralization using MEG and validate its feasibility. Methods: Magnetic fields were obtained in 12 neurosurgical candidates and one volunteer for language tasks, with a 306 channel whole head MEG. Language tasks were word listening, reading and picture naming. We tested two word listening paradigms: semantic decision of meaning of abstract nouns, and recognition of repeated words. The subjects were instructed to silently name or read, and respond with pushing button or not. We decided language dominance according to the number of acceptable equivalent current dipoles (ECD) modeled by sequential single dipole, and the mean magnetic field strength by root mean square value, in each hemisphere. We collected clinical data including Wada test. Results: Magnetic fields evoked by word listening were generally distributed in bilateral temporoparietal areas with variable hemispheric dominance. Language tasks using visual stimuli frequently evoked magnetic field in posterior midline area, which made laterality decision difficult. Response during task resulted in more artifacts and different results depending on responding hand. Laterality decision with mean magnetic field strength was more concordant with Wada than the method with ECD number of each hemisphere. Conclusions: Word listening task without hand response is the most feasible paradigm for language lateralization using MEG. Mean magnetic field strength in each hemisphere is a proper index for hemispheric dominance.