Annals of Clinical Neurophysiology
- Volume 8 Issue 1
- /
- Pages.63-70
- /
- 2006
- /
- 2508-691X(pISSN)
- /
- 2508-6960(eISSN)
Testosterone-mediated Neuroprotection in NO Induced Cell Death of Motor Neuron Cells Expressing Wild Type or Mutant Cu/Zn Superoxide Dismutase
Cu/Zn Superoxide Dismutase 유전자 발현 운동신경세포주에서 NO 독성에 대한 Testosterone의 보호효과
- Kim, Nam Hee (Department of Neurology, Dongguk University International Hospital) ;
- Kim, Hyun Jung (Department of Neurology, College of Medicine, Seoul National University) ;
-
Kim, Manho
(Department of Neurology, College of Medicine, Seoul National University) ;
- Park, Kyung Seok (Department of Neurology, College of Medicine, Seoul National University) ;
- Lee, Kwang-Woo (Department of Neurology, College of Medicine, Seoul National University)
- 김남희 (동국대학교 의과대학 일산병원 신경과학교실) ;
- 김현정 (서울대학교 의과대학 신경과학교실) ;
-
김만호
(서울대학교 의과대학 신경과학교실) ;
- 박경석 (서울대학교 의과대학 신경과학교실) ;
- 이광우 (서울대학교 의과대학 신경과학교실)
- Published : 2006.06.30
Abstract
Background: Testosterone is reported to have neuroprotective effect in various neurological diseases. Recently, the mechanism involved in nitric oxide (NO)-mediated motor neuron death is under extensive investigation. The Cu/Zn-superoxide dismutase (SOD1) mutations has been implicated in selective motor neuron death of amyotrophic lateral sclerosis (ALS) and it is said to play an important role in NO-mediated motor neuron death. However, neuroprotective effect of testosterone on motor neuron exposed to NO has rarely been studied. Methods: Motor neuron-neuroblastoma hybrid cells expressing wild-type or mutant (G93A or A4V) SOD gene were treated with
Keywords
- Amyotrophic lateral sclerosis;
- Testosterone;
- Nitric Oxide;
- Neuroprotection;
- Cu/Zn superoxide dismutase;
- Cell viability