SUGICAL TREATMENT OF MUCOSITIS AND FUNGAL INFECTION IN THE ACUTE LEUKEMIC PATIENTS

급성 백혈병 환자에서 점막 질환과 진균감염의 외과적 처치

  • Ha, Won-Suk (Div. of Oral & Maxillofacial Surgery, Dept. of Dentistry, The Catholic University of Korea) ;
  • Ye, Young-Geun (Div. of Oral & Maxillofacial Surgery, Dept. of Dentistry, The Catholic University of Korea) ;
  • Park, Jae-Hong (Div. of Oral & Maxillofacial Surgery, Dept. of Dentistry, The Catholic University of Korea) ;
  • Pyo, Sung-Un (Div. of Oral & Maxillofacial Surgery, Dept. of Dentistry, The Catholic University of Korea) ;
  • Yun, Hyun-Jung (Div. of Oral & Maxillofacial Surgery, Dept. of Dentistry, The Catholic University of Korea) ;
  • Lee, Sang-Hwa (Div. of Oral & Maxillofacial Surgery, Dept. of Dentistry, The Catholic University of Korea)
  • 하원석 (가톨릭대학교 의과대학 치과학교실 구강악안면외과) ;
  • 예영근 (가톨릭대학교 의과대학 치과학교실 구강악안면외과) ;
  • 박재홍 (가톨릭대학교 의과대학 치과학교실 구강악안면외과) ;
  • 표성운 (가톨릭대학교 의과대학 치과학교실 구강악안면외과) ;
  • 윤현중 (가톨릭대학교 의과대학 치과학교실 구강악안면외과) ;
  • 이상화 (가톨릭대학교 의과대학 치과학교실 구강악안면외과)
  • Published : 2006.03.31

Abstract

It is generally known that mucositis which often occur on hematopoietic disease patients, shows local necrosis of oral mucosa when the CBC is below the normal range. But sometimes, the lesions are occasionally infiltrate into adjacent tissue. When the pathologic destructive expansion is occurred, differential diagnosis with fungal infection, one of opportunistic infections, is needed. This means treatment and prognosis can be changed according to the diagnosis. So the diagnostic process is more important in this hematopoietic disease patients. In case of fungal infection, the range of tissue damage can expand broadly, and also proper antifungal agent and surgical extirpation should be done. After operation, continuous antifungal therapy and observations are needed. We made a comparative study of following 2 cases of fungal infection appeared on the acute lymphatic leukemia patients to discuss what the proper surgical treatment and medications are, and when the proper surgical intervention time is.

Keywords

References

  1. Lee JT, Ryu MJ, Lee KB et al : Discussion of remission failure in adult acute myelogenous leukemic patient. Kor J of Internal Med 29 : 2, 1985
  2. Estey EH, Keating MJ, McCredive KB et al : Causes of initial remission failure in acute myelogenous leukemia. Blood 60 : 30, 1982
  3. Turhal NS : Efficacy of treatment to relieve mucositisinduced discomfort. Support Care Cancer 55 : 8, 2000
  4. Lee DK, Back JY, Seo JP et al : Fungal infection in the hematopoietic patients. Kor J of Internal Med 20 : 17, 1984
  5. Shin WS, Park SY, Kim CC et al : Analysis of the infection in the acute leukemia. Kor J of Internal Med 27 : 1300, 1984
  6. Lee MS, Oh YD, Seo CW et al : Study of the infection in the acute leukemia. Kor J of Internal Med 27 : 1305, 1984
  7. Jin JY, Hong YS, Kim HK et al : Complete remission induction for patients with acute myelogenous leukemia. Kor J of Internal Med 30 : 1, 1986
  8. Passe S : Acute nonlymphoblastic leukemia. Cancer 46 : 1731, 1980 https://doi.org/10.1002/1097-0142(19801015)46:8<1731::AID-CNCR2820460805>3.0.CO;2-I
  9. Gale RP : Intensive chemotherapy for acute myelogenous leukemia. Ann Inter Med 94 : 753, 1981 https://doi.org/10.7326/0003-4819-94-6-753
  10. Gale RP : Advances In the treatment of acute myelogenous leukemia. New Eng J Med 300 : 1189, 1979 https://doi.org/10.1056/NEJM197905243002105
  11. Champlin R, Gale RP : Acute lymphoblastic Leukemia : recent advances in biology and therapy. Blood 73 : 2051, 1989
  12. Hoelzer D, Gale RP : Acute lymphoblastic Leukemia in adult. Seminar Hematol 24 : 27, 1987
  13. Foon KA, Todd RF : Immunologic classification of leukemia and lymphoma. Blood 68 : 1, 1986
  14. Omura GA, Moffitt S, Volgler R et al : Combination chemotherapy of adult acute lymphoblastic leukemia with randomized central nervous system prophylaxis. Blood 55 : 199, 1980
  15. Linker CA, Levitt LJ, O'Donnell M, et al : Improved results of treatment of adult acute lymphoblastic leukemia. Blood 69 : 1242, 1987
  16. Enno A, Golman JM, Galton DAG : Cotrimetoxazole for prevention of infection in acute leukemia : Lancet 2 : 395, 1978
  17. Anderson PM, Schroder G, Skubitz KM : Oral glutaminereduces the duration and severity of stomatitis after cytotoxic chemotherapy. Cancer 83 : 1433, 1998 https://doi.org/10.1002/(SICI)1097-0142(19981001)83:7<1433::AID-CNCR22>3.0.CO;2-4
  18. Bodey GP : Current status of prophylaxis of infection protective environments. American J Med 76 : 638, 1984
  19. Admietz IA, Rahn R, Reimer K : Prophylaxis with povidone- iodine against induction of oral mucositis by radiochemotherapy. Support Care Cancer 6 : 373, 1998 https://doi.org/10.1007/s005200050179
  20. Enno A, Golman JM, Galton DAG : Cotrimetoxazole for prevention of infection in acute leukemia. Lancet 2 : 395, 1978