Association between Panic Disorder and Dopamine D2 Receptor TaqI A Polymorphism

공황장애와 도파민 D2 수용체 TaqI A 다형성의 관련

  • Lim, Se-Won (Department of Psychiatry, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital) ;
  • Kim, Bum-Jo (Department of Psychiatry, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital) ;
  • Oh, Kang-Seob (Department of Psychiatry, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital) ;
  • Lee, Min-Soo (Department of Psychiatry, Korea University College of Medicine)
  • 임세원 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 김범조 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 오강섭 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 이민수 (고려대학교 의과대학 신경정신과학교실)
  • Received : 2006.05.19
  • Accepted : 2006.06.07
  • Published : 2006.06.30

Abstract

Puropse : Disturbances of dopaminergic system might be related to the possible mechanism of panic disorder. This study was aimed to examine the association of DRD2 Taq 1 polymorphism and panic disorder. Methods : One hundred and fourteen patients with panic disorder (62 male (54.4%), mean age $40.96{\pm}0.11$ years) and 200 comparison subjects (114 male (57.0%), mean age $35.57{\pm}8.81$ years)were tested for DRD2 TaqI A polymorphism. We excluded panic patients with comorbid alcohol related disorders, bipolar disorders, and any kinds of psychotic disorders because there have been some reports about association of these disease and DRD2 TaqI A polymorphism. Results : There was significant difference in the frequency of the genotype in DRD2 polymorphism between patients and controls (${\chi}^2$=6.09, df=2, p=0.048). The A1+ allele (A1A1 and A1A2) frequency analysis also showed significant association (${\chi}^2$=4.08, df=1, p=0.043). In addition, we observed a more strong and specific association between panic disorder and the A1+ allele of the DRD2 TaqI polymorphism for men (${\chi}^2$=4.71, df=1, p=0.03), but not for women (${\chi}^2$=0.45, df=1, p=0.50). Conclusion : These results in our Korean sample suggest that the DRD2 TaqI A polymorphism may be associated with panic disorder. Furthermore, we found sex-specific association of DRD2 A1 allele with panic disorder.

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