Keum-Ryung-Ja-San, an Traditional Herbal Prescription, Ameliorates Depressive Behaviors in Mice

  • Jung Ji-Wook (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Lee Seung-Joo (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Yoon Byung-Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Kim Dong-Hyun (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Ryu Jong-Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, East-west Pharmaceutical Research Institute, College ofPharmacy, Kyung Hee University)
  • Published : 2006.06.01

Abstract

Depression is a very difficult disease to be cured because several nervous systems are involved. In the present study, we evaluated the effects of Keum-Ryung-Ja-San (KRJS), a traditional herbal prescription, on depressive behaviors in mice using the forced swimming test. KRJS was given 1 h prior to the forced swimming test (50, 100, 200, an400 mg/kg, p.o.). The duration of immobility time in the forced swimming test was significantly reduced by KRJS treatment (200 mg/kg, P<0.05) and similar effects were observed with a classical antidepressant, imipramine (15 mg/kg, i.p.). With subchronic administrations of KRJS and its constituents at several doses for 1 week, a decreased duration of immobility time was observed with KRJS and Corydalis ternata (200 mg/kg, p.o. P<0.05). These results suggest that KRJS may have antidedpressive activities and CT may contribute to the antidepressive activity of KRJS.

Keywords

References

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