Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Green Tea Catechin Causes an Weight Loss in Transgenic Mice Over-expressing Carboxyl Terminus of Amyloid Precusor Protein

  • Lim Hwa-J. (College of Pharmacy, Ewha Womans University) ;
  • Kim Yong-K. (Division of Laboratory Animal Resources, Korea Food and Drug Administration, National Institute of Toxicological Research) ;
  • Sheen Yhun-Y. (College of Pharmacy, Ewha Womans University)
  • Published : 2006.06.01
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Abstract

Amyloid$\beta(A{\beta})$ has been reported have an effect on the induction of oxidative stress that involves the functional and structural abnormalities in Alzheimer's disease. As a role of a radical scavenger, a green tea treatment was found have some inhibitory effect on the neurodegenerative process. The aim of this study was to determine if green tea catechin (GTC) reduces in transgenic model. To test this, transgenic mice carrying neuronspecific enolase (NSE) controlled C-terminus (105) of APP (APP-C105) were created and treated them with a low ana high dose of GTC for 6 months. Herein, we conclude that transgenic mice expressing NSE/APP-C105 were successfully created and the GTC-treated group exhibited significant reduction in body weight. Thus, GTC might be a good prevention of obesity or good treatment for AD patient.

Keywords

References

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