Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Regulatory Effects of Samul-tang on Axonal Recovery after Spinal Cord Injury in Rats

  • Lee, Ki-Tae (Department of Oriental Medicine, Daejeon University) ;
  • Kim, Yoon-Sik (Department of Oriental Medicine, Daejeon University) ;
  • Ryu, Ho-Ryong (Department of Oriental Medicine, Daejeon University) ;
  • Jo, Hyun-Kyeng (Department of Oriental Medicine, Daejeon University) ;
  • An, Jung-Jo (Department of Oriental Medicine, Daejeon University) ;
  • Namgung, Uk (Department of Oriental Medicine, Daejeon University) ;
  • Seol, In-Chan (Department of Oriental Medicine, Daejeon University)
  • Published : 2006.10.25
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Abstract

In oriental medicine, Samul-tang (SMT) has been used for the treatment of cardiovascular diseases and neuronal disorders. Here, possible effects of SMT on axonal regeneration after the spinal cord injury were examined. SMT treatment induced increases in regeneration-related proteins GAP-43, cell division cycle 2 (Cdc2) and phospho-Erk1/2 in the peripheral sciatic nerves after crush injury. Increased levels of Cdc2 and phospho-Erk1/2 were observe mostly in the gray matter area and some in the dorsomedial white matter. These increases correlated with increased cell numbers in affected areas. Moreover, axons of corticospinal tract (CST) showed increased sprouting in the injured spinal cord when administrated with SMT compared with saline-treated control. Thus, the present data indicate that SMT may be useful for identifying active components and for therapeutic application toward the treatment of spinal cord disorders after injury.

Keywords

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