동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제20권6호
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  • Pages.1672-1677
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  • 2006
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

Modulation of Sarcodon Aspratus on lon Currents-induced by Excitatory Neurotransmitters in Rat Periaqueductal Gray Neurons

  • Kim, Sung-Tae (Department of Anatomy-Pointology, College of Oriental Medicine, Kyungwon University) ;
  • Sung, Yun-Hee (Department to Physiology, College of Medicine, Kyung Hee University) ;
  • Kim, Chang-Ju (Department to Physiology, College of Medicine, Kyung Hee University) ;
  • Joo, Kwan-Joong (Department of Urology, College of Medicine, Sungkyunkwan Univeristy) ;
  • Han, Seung-Ho (Department of Physiology, College of Medicine, Eulji University) ;
  • Lee, Choong-Yeol (Department of Physiology, College of Oriental Medicine, Kyungwon University) ;
  • Kim, Youn-Sub (Department of Anatomy-Pointology, College of Oriental Medicine, Kyungwon University)
  • 발행 : 2006.12.25
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초록

Sarcodon aspratus is the mushroom of Telephoracea which was been classified into Alphllophorales. The aqueous extract of Sarcodon aspratus in known to have anti-tumor activity, immune modulatory effect, and anti-oxidative action. The descending pain control system consists of three major components: the periaqueductal gray (PAG) of the midbrain, the rostroventral medulla including the nucleus raphe magnus, and the spinal dorsal horn. Glutamate is the primary excitatory neurotransmitter in the brain. Glutamate ionotropic receptors are classified as N-methyl-D-aspartate (NMDA) receptor, ${\alpha}$-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor, and kainate receptor. In the present study, the modulation of Sarcodon aspratus on the ion currents activated by glutamate, NMDA, AMPA, and kainate in the acutely dissociated PAG neurons was investigated by nystatin-perforated patch-clamp technique under boltage-clamp condition. Sarcodon aspratus increased glutamate- and NMDA-induced ion currents were not increased by Sarcodon aspratus. The present results show that Sarcodon aspratus may activate the descending pain control system in rat PAG neurons through NMDA receptor.

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참고문헌

  1. Fields, H.L., Heinricher, M.M., Mason, P. Neurotransmitters in nociceptive modulatory circuits. Annu Rev Neurosci 14: 219-245, 1991 https://doi.org/10.1146/annurev.ne.14.030191.001251
  2. Basbaum, A.I., Fields, H.L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7: 309-338, 1984 https://doi.org/10.1146/annurev.ne.07.030184.001521
  3. Greenamyre, J.T., Young, A.B., Penney, J.B. Quantitative autoradiographic distribution of $L-[^3H]$ glutamate-binding sites in rat central nervous system. J Neurosci 4: 2133-2144, 1984 https://doi.org/10.1523/JNEUROSCI.04-08-02133.1984
  4. Silva, E., Hernandez, L., Contreras, Q., Guerrero, F., Alba, G. Noxious stimulation increases glutamate and arginine in the periaqueductal gray matter in rats: a microdialysis study. Pain 87: 131-135, 2000 https://doi.org/10.1016/S0304-3959(00)00275-X
  5. Dingledine, R., Borges, K., Bowie, D., Traynelis, S.F. The glutamate receptor ion channels. Pharmacol Rev 51: 7-61, 1999
  6. Kim, J.W., Moon, B.S., Park, Y.M., Yoo, N.H., Yoo, I.J., Yoo, I.D., Kim, J.P., Nguyen, T.C. Structures and Antioxidant Activity of Diketopiperazines Isolated from the Mushroom Sarcodon aspratus. J Korean Soc Appl Biol Chem 48: 93-97, 2005
  7. Song, J.H., Lee, H.S., Hwang, J.K., Han, J.W., Ro, J.G., Keum, D.H., Park, K.M. Physiological activity of Sarcodon aspratus Extracts. Korean J Food Sci Ani Resour 23: 172-179, 2003
  8. Han, S.H., Cho, Y.W., Kim, C.J., Min, B.I., Rhee, J.S., Akaike, N. Mu-opioid agonist-induced activation of G-protein-coupled inwardly rectifying potassium currents in rat periaqueductal gray neurons. Neuroscience 90: 209-219, 1999 https://doi.org/10.1016/S0306-4522(98)00409-6
  9. Kim, Y., Shin, M., Chung, J., Kim, E., Koo, G., Lee ,C., Kim, C. Modulation of Chelidonii herba on GABA activated chloride currents in rat PAG neurons. Am J Chin Med 29: 265-279, 2001 https://doi.org/10.1142/S0192415X01000290
  10. Bliss, T.V.P., Collingridge, G.L. A synaptic model ofmemory: long-term potentiation in the hippocampus. Nature 361: 31-39, 1993 https://doi.org/10.1038/361031a0
  11. Woolf, C.J., Salter, M.W. Neuronal plasticity: increasing the gain in pain. Science 288: 1765-1769, 2000 https://doi.org/10.1126/science.288.5472.1765
  12. Urca, G., Nahin, R.L., Liebeskind, J.C. Glutamate-induced analgesia: blockade and potentiation by naloxone. Brain Res 192: 523-530, 1980 https://doi.org/10.1016/0006-8993(80)90902-6
  13. Maione, S., Marabese, I., Leyva, J., Palazzo, E., De Novellis, B., Rossi, F. Characterization of mGluRs which modulate nociception in the PAG of the mouse. Neuropharmacology 37: 1475-1483, 1998 https://doi.org/10.1016/S0028-3908(98)00126-9
  14. Jensen, T.S., Yaksh, T.L. Brainstem excitatory amino acid receptors in nociception microinjection mapping and pharmacological characterization of glutamate sensitive sites in the brainstem associated with algogenic behavior. Neuroscience 46: 535-547, 1992 https://doi.org/10.1016/0306-4522(92)90142-O
  15. Coderre, T.J., Katz, J., Vaccarino, A.L., Melzack, R. Contribution of central plasticity to pathological pain: review of clinical and experimental evidence. Pain 52: 259-285, 1993 https://doi.org/10.1016/0304-3959(93)90161-H
  16. Suh, H.W., Song, D.K., Choi, Y.S., Kim, Y.H. Multiplicative interaction between intrathecally and intracerebroventricularly administered morphine for antinociception in the mouse: Involvement of supraspinal NMDA but not non-NMDA receptors. Life Sci 56: 181-185, 1995 https://doi.org/10.1016/0024-3205(94)00498-H
  17. Hizue, M., Pang, CH., Yokoyama, M. Involvement of N-methyl-D-aspartate-type glutamate receptor epsilon1 and epsilon4 subunits in tonic inflammatory pain and neuropathic pain. Neuroreport 16: 1667-1670, 2005 https://doi.org/10.1097/01.wnr.0000183328.05994.9e
  18. Hollmann, M., Hartley, M., Heinemann, S. $Ca^{2+}$permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 252: 851-853, 1991 https://doi.org/10.1126/science.1709304
  19. Zhuo, M. Silent glutamatergic synapses and long-term facilitation in spinal dorsal horn neurons. Prog Brain Res 129: 101-113, 2000 https://doi.org/10.1016/S0079-6123(00)29008-0
  20. Urban, M.O., Coutinho, S.V., Gebhart, G.F. Involvement of excitatory amino acid receptors and nitric oxide in the rostral ventromedial medulla in modulating secondary hyperalgesia produced by mustard oil. Pain 81: 45-55, 1999 https://doi.org/10.1016/S0304-3959(98)00265-6
  21. Yasukawa, K., Aoki, T., Takido, M., Ikekawa, T., Saito, H., Matsuzawa, T. Inhibitory effects of ergosterol isolated from the edible mushroom Hypsizigus marmoreus on TPA-induced inflammatory ear oedema and tumour promotion in mice. Phytother Res 8: 10-13, 1994 https://doi.org/10.1002/ptr.2650080103
  22. Bok, J.W., Lermer, L., Chilton, J., Klingeman, H.G., Towers, G.H. Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochemistry 51: 891-898, 1999 https://doi.org/10.1016/S0031-9422(99)00128-4
  23. Zhang, Y., Mills, G.L., Nair, M.G. Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. J Agric Food Chem 50: 7581-7585, 2002 https://doi.org/10.1021/jf0257648