Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Cnidium officinale, Petasites japonicus, Coptis chinensis Extract Mixture on Vasodilation

천궁(川芎), 머위, 황련(黃連) 추출물 조성의 $Ca^{2+}$ 유입 억제를 통한 혈관이완 효능

  • Kim, Sang-Dae (Department of Physiology, college of Oriental Medicine, Dongguk University) ;
  • 김길훤, Gil-Whon (Department of Physiology, college of Oriental Medicine, Dongguk University) ;
  • Shin, Heung-Mook (Department of Physiology, college of Oriental Medicine, Dongguk University)
  • 김상대 (동국대학교 한의과대학 생리학교실) ;
  • 김길훤 (동국대학교 한의과대학 생리학교실) ;
  • 신흥묵 (동국대학교 한의과대학 생리학교실)
  • Published : 2006.12.25
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Abstract

This study was performed to investigate a vasodilatory efficacy and its underlying mechanisms of the mixture of Cnidium officinale, Petasites japonicus and Coptis chinensis (CPC), CPC relaxed rat aortic vascular strips in endothelium-independant manner precontracted with phenylephrine or KCI(50mM), but the magnitude of relaxation was greater in KCI induced contraction. L-NAME, iNOS inhibitor, and methylen blue(MB), cGMP inhibitor, did not attenuate the relaxation responses of CPC. Furthermore, the contraction by increaseing $Ca^{2+}$ concentration (0.3-10.0mM) to a $Ca^{2+}$-free high $K^+$ (60mM) was significantly reduced by CPC pretreatment. These results suggest that the relaxation effect of CPC is related with the block of $Ca^{2+}$ influx via $Ca^{2+}$ channel.

Keywords

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