Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Experimental Efects of Acanthopanax sessiliflorus $S_{EEM}$ Extracts Following Gamma-ray Irradiation on the Body Weight and Serum Lipid Level in Obesity-induced Mice, Regional Cerebral Blood Flow and Blood Pressure in Normal Rats

방사선이 조사된 오갈피 나무의 추출물이 비만 생쥐의 체중 및 혈청내 지질 함량, 정상 흰쥐의 국소 뇌혈류량과 혈압에 미치는 실험적 효과

  • Cho, Su-In (College of Oriental Medicine, Dongshin University) ;
  • Kim, Hyung-Woo (College of Oriental Medicine, Dongshin University) ;
  • Jeong, Sun (College of Oriental Medicine, Dongshin University) ;
  • Jeon, Byung-Gwan (Department of Environmental Engineering, Donshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University) ;
  • Jeong, Hyun-Woo (College of Oriental Medicine, Dongshin University)
  • 조수인 (동산대학교 한의과대학) ;
  • 김형우 (동산대학교 한의과대학) ;
  • 정선 (동산대학교 한의과대학) ;
  • 전병관 (동신대학교 환경공학과) ;
  • 김계엽 (동신대학교 물리치료학과) ;
  • 정현우 (동산대학교 한의과대학)
  • Published : 2006.12.25
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Abstract

This experimental study was designed to investigate the effects of Acanthopanax sessiliflorus $S_{EEM}$ extracts following gamma-ray irradiation on the change of weight, the serum total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, free fatty acid, total lipid, phospholipid level in obese mice induced by high fat diet, and the change of regional cerebral blood flow (rCBF) and blood pressure (BP) in normal rats. Experimental materials were as follows ; 10AS was the bark powder of Acanthopanax sessiliflorus $S_{EEM}$ stems which was exposed in 10 kGy electron beam, 10AS was the bark powder of Acanthopanax sessiliflorus $S_{EEM}$ roots which was exposed in 10 kGy electron beam, 100S was the bark powder of Acanthopanax sessiliflorus $S_{EEM}$ stems which was exposed in 100 kGy electron beam, Experimental groups were as follows ; Normal group was fed with normal diet and administered with distilled water during 5 weeks, Control group was fed with high fat diet and administered with distilled water during 5 weeks, Sample A group was fed with high fat diet and administered with 10AS of 300 mg/kg/mouse/day during 5 weeks, Sample B group was fed with high fat diet and administered with 10AR of 300 mg/kg/mouse/day during 5 weeks, Sample C group was fed with high fat diet and administered with 100AS of 300 mg/kg/mouse/day during 5 weeks. The results were as follows ; Sample A group, Sample B group and Sample C group were significantly decreased body weight and the serum LDL-cholesterol, triglyceride, total lipid level in comparison with Control group. Sample A group, Sample B group and Sample C group were significantly increased the serum HDL-cholesterol level in comparison with Control group. Sample B group and Sample C group were significantly decreased the serum total cholesterol, free fatty acid and phospholipid level in comparison with Control group. This results were suggested that all experimental materials were able to be used for the obesity. 10AS did not changed rCBF and MABP in a dose-dependent manner. 10AR significantly increased rCBR in a dose-dependent manner, and BP did not change in a dose-dependent manner. 100AS decreased rCBF and BP in a dose-dependent manner. This results were suggested that 10 AR significantly increased rCBF by dilating pial arterial diameter. According to above results, the authors suggested that 10AR was able to be used for the obesity and ischemic disease.

Keywords

References

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