Childhood Kidney Diseases
- Volume 10 Issue 1
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- Pages.1-7
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- 2006
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- 2384-0242(pISSN)
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- 2384-0250(eISSN)
Osteopontin and Developing Kidney
Osteopontin과 신장 발달
- Yim Hyung-Eun (Department of Pediatrics, College of Medicine, Korea University) ;
- Yoo Kee-Hwan (Department of Pediatrics, College of Medicine, Korea University)
- Published : 2006.04.01
Abstract
Osteopontin (OPN) is a glycosylated phosphoprotein which mediates cell adhesion and migration, and is produced by bone, macrophages, endothelial cells, and epithelial cells. The many regulatory functions of OPN include bone remodeling, tumor invasion, wound repair, and promotion of cell survival. It is produced by renal tubular epithelial cells, and expression is upregulated in glomerulonephritis, hypertension, ischemic acute renal failure, renal ablation, and UUO. In this review, we discuss about osteopontin in general aspect, expression, role on the development and pathologic condition of neonatal kidney.