Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
권호 표지

Osteopontin and Developing Kidney

Osteopontin과 신장 발달

  • Yim Hyung-Eun (Department of Pediatrics, College of Medicine, Korea University) ;
  • Yoo Kee-Hwan (Department of Pediatrics, College of Medicine, Korea University)
  • 임형은 (고려대학교 의과대학 소아과학교실) ;
  • 유기환 (고려대학교 의과대학 소아과학교실)
  • Published : 2006.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

Osteopontin (OPN) is a glycosylated phosphoprotein which mediates cell adhesion and migration, and is produced by bone, macrophages, endothelial cells, and epithelial cells. The many regulatory functions of OPN include bone remodeling, tumor invasion, wound repair, and promotion of cell survival. It is produced by renal tubular epithelial cells, and expression is upregulated in glomerulonephritis, hypertension, ischemic acute renal failure, renal ablation, and UUO. In this review, we discuss about osteopontin in general aspect, expression, role on the development and pathologic condition of neonatal kidney.

Keywords