Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Radical Scavenging Hydroxyphenyl Ethanoic Acid Derivatives from a Marine-Derived Fungus

  • Li Xifeng (Department of Chemistry, Pukyong National University) ;
  • Kim Se-Kwon (Department of Chemistry, Pukyong National University) ;
  • Kang Jung-Sook (College of Dentistry, Pusan National University) ;
  • Choi Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Son Byeng-Wha (Department of Chemistry, Pukyong National University)
  • Published : 2006.04.01
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Abstract

Bioassay-guided fractionation of an organic extract of the culture broth from an unidentified marine-derived fungus led to the isolation of a new metabolite, N-[2-(4-hydroxyphenyl) acetyl]formamide (1), along with four known polyketides, 4-hydroxyphenyl acetamide (2), 4-hydroxyphenyl acetic acid (3), 3,4-dihydroxyphenyl acetic acid (4), and N-[2-(4-hydroxyphenyl)ethenyl]formamide (5). The structures of 1-5 were elucidated by spectral data analyses. Among them, compounds 1, 4, and 5 exhibited significant radical scavenging activity against 1, 1-diphenyl-2-picrylhydrazyl (DPPH) with $IC_{50}$ values of 8.4, 11.9, and $0.2{\mu}M$, respectively.

Keywords

References

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