Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
권호 표지

흰쥐의 사염화탄소로 유도된 간손상에 미치는 9-Amino-1, 2, 3, 4-tetrahydroacridine의 영향

Effect of 9-Amino-1, 2, 3, 4-tetrahydroacridine on $CCl_4$-Induced Liver Injury in Rats

  • 신혜순 (덕성여자대학교 약학대학) ;
  • 조은정 (덕성여자대학교 약학대학)
  • Shin Hea-Soon (College of Pharmacy, Duksung Women's University) ;
  • Cho Eun-Jung (College of Pharmacy, Duksung Women's University)
  • 발행 : 2006.03.01
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초록

This study was done to investigate the protective effect of novel 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives on the hepatoprotective effect intoxicated rats induced by carbon tetrachloride ($CCl_4$). A series of currently derivatives of 9-amino-1, 2, 3, 4-tetrahydroacridine have been prepared through the alkly substitution or the ring expansion for the treatment of the Alzheimer's disease. The activities of aminotransferase (aspartate and alanine) and contents of alkaline phosphatase, triglyceride and glutathione S-transferase in 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives pretreated rats were significantly decreased compared to the only carbon tetrachloride treated rats but the contents of cholesterol were increased compared to the only $CCl_4$ treated rats. The result indicated that 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives showed hepatoprotective effect in $CCl_4$ treated rats.

키워드

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