Journal of Preventive Medicine and Public Health

  • 제39권2호
  • /
  • Pages.135-140
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  • 2006
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  • 1975-8375(pISSN)
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  • 2233-4521(eISSN)
대한예방의학회 (The Korean Society for Preventive Medicine)
권호 표지

위암 환자에서 Glutathione S-transferases (GSTM1, GSTT1, GSTP1) 및 N-acetyltransferase 2 유전자 다형성 분포

Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 Polymorphisms and the Risk of Gastric Cancer

  • 홍수형 (경북대학교 치의학전문대학원 구강미생물학교실) ;
  • 김정완 (경북대학교 치의학전문대학원 구강미생물학교실) ;
  • 김호각 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 박인규 (경북대학교 의학전문대학원 치료방사선과학교실) ;
  • 류준욱 (경북대학교 치의학전문대학원 구강미생물학교실) ;
  • 이창형 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 손윤경 (경북대학교 의학전문대학원 병리학교실) ;
  • 이종영 (경북대학교 의학전문대학원 예방의학교실)
  • Hong, Su-Hyung (Department of Dental Microbiology, Kyungpook National University School of Dentistry) ;
  • Kim, Jung-Wan (Department of Dental Microbiology, Kyungpook National University School of Dentistry) ;
  • Kim, Ho-Gak (Department of Internal Medicine, Catholic University of Daegu School of Medicine) ;
  • Park, In-Kyu (Department of Therapeutic Radiology, Kyungpook National University School of Medicine) ;
  • Ryoo, Jun-Wook (Department of Dental Microbiology, Kyungpook National University School of Dentistry) ;
  • Lee, Chang-Hyeong (Department of Internal Medicine, Catholic University of Daegu School of Medicine) ;
  • Sohn, Yoon-Kyung (Department of Pathology, Kyungpook National University School of Medicine) ;
  • Lee, Jong-Young (Department of Preventive Medicinee, Kyungpook National University School of Medicine)
  • 발행 : 2006.03.01
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초록

Objectives : Polymorphisms of genes from glutathione Stransferases (GSTs) and N-acetyltransferase 2 (NAT2) have been associated with increased susceptibility to various cancers. Previous results showed that East Asians such as Koreans, Japanese and Chinese have a much higher frequency of the GSTM1 and GSTT1 null genotypes and NAT2 rapid acetylator type. Therefore, we investigated the association between the polymorphic types of GSTs (GSTM1, GSTT1, GSTP1) and NAT2 and the incidence of gastric cancer which is one of the most prevalent cancers among the East Asians. Methods : It was performed in a case-control study consisting of 238 healthy subjects and 108 cancer patients (54 distal and 54 proximal carcinomas). We also evaluated the association between GSTs and NAT2 and the risk factors for gastric cancer such as alcohol consumption, smoking, H. pylori infection, family history of gastric cancer, and tumor location. Results : In our study, the percentage of cases whose hometown was rural was higher than those of controls (odds ratio (OR) =2.88; 95% CI=1.72-4.76), and the frequency of the lower socio-economic status increased significantly in patients (OR=2.53; 95% CI=1.59-4.02). There was no significant difference in the GST polymorphic types between the cases and controls. However, NAT2 rapid or intermediate acetylator types were frequently detected in the cases with family history of gastric cancer (OR=1.92; 95% CI=1.79-26.0). Conclusions : These results suggest that the hometown and socio-economic status are important environmental factors for gastric carcinogenesis, and NAT2 polymorphic types could be associated with familial gastric carcinoma.

키워드

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