Journal of Yeungnam Medical Science
- Volume 23 Issue 1
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- Pages.52-61
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- 2006
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- 2799-8010(eISSN)
The Effects of Ginseng Saponin on Relaxation of Smooth Muscle in the Lower Urinary Tract and the Corpus Cavernosum
인삼 사포닌이 하부요로와 음경해면체 평활근의 이완작용에 미치는 효과
- Jung, Hee-Chang (Department of Urology, College of Medicine, Yeungnam University) ;
- Oh, Tae-Hee (Department of Urology, Sungkyungwan University Masan Samsung Hospital)
- Published : 2006.06.30
Abstract
Background: Korean ginseng (KG) has been used as a general tonic, and for voiding dysfunction for a long time in oriental society. However, scientific basic studies on the use of KG, have been rare, especially for voiding and erectile dysfunction. This study was performed to investigate the effects of KG on voiding and erectile function by examining the effects of total saponin (TS) on the bladder, urethral and penile cavernosal smooth muscle. Materials and methods: To examine the effects of TS, NewZeland white rabbits were used to obtain tissue strips from the smooth muscle of the bladder, proximal urethra and corpus cavernosum. Adult Sprague Dawley rats were used to examine the changes in urodynamic findings and penile erection after administration of TS. Results: In proximal urethral strips, the rate of relaxation of the proximal urethra was increased from
이상의 결과를 종합하면, 인삼 총사포닌은 본 실험의 조건에서 배뇨개선 효과가 있으며 이에 관여하는 총사포닌의 주 효능은 근위부요도를 이완시킴으로써 이루어지는 것으로 생각된다. 그리고 인삼 총사포닌은 혈류역동학적으로 안전하게 음경해면체 평활근을 이완시켜 음경발기를 유발시키는 것으로 생각된다.