The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Effects of Taraxaci Herba on Surgically Induced Endometriosis in Rats

포공영(浦公英) 추출물이 자궁내막증 유발 백서(白鼠)에 미치는 영향

  • Lim, Eun-Mee (Dept. of Gynecology, Oriental Medicine, Kyungwon University) ;
  • Lee, Eun (Dept. of Bioindustry and technology, College of Life Science & Natural Resources, Sangji University) ;
  • Park, Jun-Sik (Dept. of Gynecology, Oriental Medicine, Kyungwon University)
  • 임은미 (경원대학교 한의과대학 부인과학교실) ;
  • 이은 (상지대학교 생명자원과학대학 생명산업학과) ;
  • 박준식 (경원대학교 한의과대학 부인과학교실)
  • Published : 2006.08.31
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Abstract

Purpose : Taraxaci Herba is a herb with an effect on extravasated blood and is widely used in gynecology. This study examined the effects of Taraxaci Herba on endometriosis. Methods : Rats with surgically induced endometriosis were given an oral dose of Taraxaci Herba for 40 days. The size of the ectopic uterine implants at the serosal wall and the concentration of progesterone, estradiol, tumor necrosis factor-${\alpha}$(TNF-${\alpha}$) and interleukin(IL)-2, 4, 6, and 10 in the blood were examined and compared with the control group. Results : The size of the ectopic uterine implants in the treated group was much smaller than that in the control group. The estradiol concentration was significantly lower in the experimental group than in the control group. The IL-10 level was higher and the TNF-${\alpha}$, IL-2 and IL-4 concentration were lower in the experimental group than in the control group and there was statistically significant difference. There was no significant difference in the IL-6 level between the experomental and the control group. Conclusion : These results indicate that Taraxaci Herba reduces the size of ectopic uterine implants at the serosal wall and inhibits the growth of ectopic uterine implants. This suggests that Taraxaci Herba is an effective treatment for endometriosis.

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