The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)
- Volume 19 Issue 4
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- Pages.225-244
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- 2006
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- 1229-4292(pISSN)
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- 2508-3619(eISSN)
A Clinical Study on the Effect of Daejo-hwan(DJH) on Climacteric Syndrome
갱년기(更年期) 증후군(症候群)에 미치는 대조환(大造丸)의 효과에 대한 임상 연구
- Kim, Soo-Min (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
- Shin, Sun-Mi (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
- Kim, Eui-Il (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
- Lee, Jung-Eun (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
- Yoo, Dong-Youl (Dept. of Oriental Medicine Graduate School, Daejeon University)
- 김수민 (대전대학교 한의과대학 부인과교실) ;
- 신선미 (대전대학교 한의과대학 부인과교실) ;
- 김의일 (대전대학교 한의과대학 부인과교실) ;
- 이정은 (대전대학교 한의과대학 부인과교실) ;
- 유동열 (대전대학교 한의과대학 부인과교실)
- Published : 2006.11.30
Abstract
Purpose : This study was performed to assess the clinical effect of Daejo-hwan(DJH) on climacteric syndrome, not only common symptoms such as hot flushes, anxiety, palpitation and so on, but also urogenital tract disturbances like vaginal dryness and sexual problems. Methods : We randomly divided 120 women with the climacteric syndrome into two groups. One group received only DJH 2 pills(4g) a time, three times a day for 8 weeks and the other group didn't get any treatment for the same period. We evaluated sonography, DXA, blood test, female hormone test and questionnaires in the beginning as well as after 8 weeks of the treatment. Symptoms were measured by Kupperman's index, Menopausal Rating Scale and the Greene Climacteric Scale. Results : In this study, DJH was innoxious on liver and kidney. And DJH in the treated group reduced climacteric symptoms significantly as compared to the control group without enlargement of uterus myoma and the change of estradiol. In Kupperman's index and MRS, DJH in the treated group especially had effects on fatigue, shoulder pain. anxiety, headache, hot flushes as well as sexual problems. Conclusion : These results suggest that DJH can be useful in treating various climacteric symptoms including sexual problems without influences on the size of uterus myoma and estradiol.