Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Rehmannia Radix(RR) Extracts Inhibit IGF-II Induced VEGF and HIF-1 ${\alpha}$ Expressions in HaCaT Keratinocyte Cells

Rehmannia Radix의 IGF-II로 유도된 HIF-1 ${\alpha}$와 VEGF 발현 억제

  • Park, Ung (Dept. of Preventive Medicine, College of Traditional Korean Medicine, Kyunghee Univ.) ;
  • Shin, Yong-Cheol (Dept. of Preventive Medicine, College of Traditional Korean Medicine, Kyunghee Univ.) ;
  • Ko, Seong-Gyu (Dept. of Preventive Medicine, College of Traditional Korean Medicine, Kyunghee Univ.)
  • 박웅 (경희대학교 한의과대학 예방한의학교실) ;
  • 신용철 (경희대학교 한의과대학 예방한의학교실) ;
  • 고성규 (경희대학교 한의과대학 예방한의학교실)
  • Published : 2006.12.28
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Abstract

Psoriasis is a chronic skin disease characterized by angiogenesis. It has been reported that growth factor as vascular endothelial growth factor(VEGF) and insulin like growth factor(IGF) II are overexpressed in psoriatic epidermis. To investigate the inhibitory effects of IGF-II induced VEGF and HIF-1${\alpha}$ expression by RR extracts, we performed MTS assay, western blots using HaCaT cells. RR extracts significantly reduced IGF-II induced HIF 1${\alpha}$ protein level via MAPK pathway in HaCaT cells. Also, RR extracts inhibited IGF-II induced VEGF mRNA and protein expression levels in the HaCaT keratinocytes. These results suggest that inhibition of HIF-1${\alpha}$ and VEGF expressions by RR extracts contributes to the anti angiogenic effects.

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