Fabrication of a CNT Filter for a Microdialysis Chip

  • An, Yun-Ho (School of Mechanical Engineering, Hanyang University) ;
  • Song, Si-Mon (School of Mechanical Engineering, Hanyang University)
  • 발행 : 2006.12.31

초록

This paper describes the fabrication methods of a carbon nanotube (CNT) filter and a microdialysis chip. A CNT filter can help perform dialysis on a microfluidic chip. In this study, a membrane type of a CNT filter is fabricated and located in a microfluidic chip. The filter plays a role of a dialysis membrane in a microfluidic chip. In the fabrication process of a CNT filter, individual CNTs are entangled each other by amide bonding that is catalyzed by 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The chemically treated CNTs are shaped to form a CNT filter using a PDMS film-mold and vacuum filtering. Then, the CNT filter is sandwiched between PDMS substrates, and they are bonded together using a thin layer of PDMS prepolymer as adhesive. The PDMS substrates are fabricated to have a microchannel by standard photo-lithography technique.

키워드

참고문헌

  1. Dittrich, P.S., Tachikawa, K. & Manz, A. Micro Total Analysis Systems. Latest Advancements and Trends. Anal. Chem. 78(12), 3887-3908 (2006) https://doi.org/10.1021/ac0605602
  2. Vilkner, T., Janasek, D. & Manz, A. Micro Total Analysis Systems. Recent Developments. Anal. Chem. 76(12), 3373-3386 (2004) https://doi.org/10.1021/ac040063q
  3. Reyes, D.R., Iossifidis, D., Auroux, P.A., & Manz, A. Micro Total Analysis Sytems. 1. Introduction, Theory, and Technology. 74(12), 2623-2636 (2002)
  4. Auroux, P.A., Iossifidis, D., Reyes, D.R. & Manz, A. Micro Total Analysis Systems. 2. Analytical Standard Operations and Applications. Anal. Chem. 74(12), 2637-2652 (2002) https://doi.org/10.1021/ac020239t
  5. Song, S. & Singh, A.K. On-chip Sample Preconcentration for Integrated Microfluidic Analysis. Anal. Bioanal. Chem. 384, 41-43 (2006) https://doi.org/10.1007/s00216-005-0206-3
  6. Seong, G.H. & Crooks, R.M. Efficient Mixing and Reactions within Microfluidic Channels Using Microbead-Supported Catalysts. Journal of the American Chemical Society 124(45), 13360-13361 (2002) https://doi.org/10.1021/ja020932y
  7. Metz, S. et al. Polyimide Microfluidic Devices with Integrated Nanoporous Filtrartion Areas Manufactured by Micromachining and Ion Track Technology. Journal of Micromechanics and Microengineering 14, 324-331 (2004) https://doi.org/10.1088/0960-1317/14/3/002
  8. Song, S. et al. Microchip Dialysis of Proteins Using in Situ Photopatterned Nanoporous Polymer Membranes. Anal. Chem. 76(8), 2367-2373 (2004) https://doi.org/10.1021/ac035290r
  9. Song, S. et al. Electrophoretic Concentration of Proteins at Laser-Patterned Nanoporous Membranes in Microchips. Anal. Chem. 76(15), 4589-4592 (2004) https://doi.org/10.1021/ac0497151
  10. Jiang, Y. et al. Integrated Plastic Microfluidic Devices with ESI-MS for Drug Screening and Residue Analysis. Anal. Chem. 73, 2048-2053 (2001) https://doi.org/10.1021/ac001474j
  11. Xiang, F. et al. An Integrated Microfabricated Device for Dual Microdialysis and On-line ESI-Ion Trap Mass Spectrometry for Analysis of Complex Biological Samples Anal. Chem. 71, 1485-1490 (1999) https://doi.org/10.1021/ac981400w
  12. Iijima, S. Helical Microtubules of Graphitic Carbon. Nature 354, 56-58 (1991) https://doi.org/10.1038/354056a0
  13. Liu, J. et al. Fullerene Pipes. Science 280(22), 1253-1256 (1998) https://doi.org/10.1126/science.280.5367.1253
  14. Vaccarini, L. et al. Purification Procedure of Carbon Nanotubes. Synthetic Metals 103, 2492-2493 (1999) https://doi.org/10.1016/S0379-6779(98)01087-X
  15. Ziegler, K.J. et al. Cutting Single-walled Carbon Nanotubes. Nanotechnology 16, S539-S544 (2005) https://doi.org/10.1088/0957-4484/16/7/031
  16. Peng, H. et al. Sidewall Carboxylic Acid Functionalization of Single-walled Carbon Nanotubes. J. AM. CHEM. SOC. 125, 15174-15182 (2003) https://doi.org/10.1021/ja037746s
  17. Jiang, K. et al. Protein Immobilization on Carbon Nanotubes via a Two-step Process of Diimide-actived Amidation. Journal of Material Chemistry 14, 37-39 (2004) https://doi.org/10.1039/b310359e
  18. Huang, W. et al. Attaching Proteins to Carbon Nanotubes via Diimide-Activated Amidation. Nano Letters 2(4), 311-314 (2002) https://doi.org/10.1021/nl010095i
  19. Chiu, P.W. et al. Interconnection of carbon nanotubes by chemical functionalization. Applied Physics Letters 80(20), 3811-3813 (2002) https://doi.org/10.1063/1.1480487
  20. Wu, H. et al. Construction of Microfluidic Chips using Polydimethylsiloxane for Adhesive Bonding. Lab. Chip. 5, 1393-1398 (2005) https://doi.org/10.1039/b510494g