Molecular & Cellular Toxicology

The Korean Society of Toxicogenomics and Toxicoproteomics (대한독성유전 단백체학회)
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Association of PAI-1 Polymorphism with Schizophrenia in Korean Population

  • Yoon, Seo-Hyun (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Park, Hae-Jeong (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Zheng, Longtai (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Hong, Mee-Suk (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Kim, Jong-Woo (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Yim, Sung-Vin (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Chung, Joo-Ho (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University)
  • Published : 2006.09.30
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Abstract

Several reports have suggested a possible relationship between blood coagulation factors and schizophrenia. Plasminogen activator inhibitor type 1 (PAI-1) belongs to a serine protease inhibitor family, which regulates fibrinolysis and proteolysis by inhibiting plasminogen activation. The purpose of this study was to investigate the association of polymorphisms of the PAI-1 gene with schizophrenia in Korean population. Two important polymorphisms (-675 4G/5G and -844 G/A) located on promoter region of the PAI-1 gene were analyzed on 178 schizophrenia patients and 226 controls. The genotypic and allelic associations of -675 4G/5G were found significant. Furthermore, haplotype analysis revealed significant result, which suggests that -675 4G/5G polymorphism might confer increased susceptibility for schizophrenia in Korean population.

Keywords

References

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