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The Pharmaceutical Society of Korea (대한약학회)
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The Protective Effects of Phenolic Constituents from Gastrodia elata on the Cytotoxicity Induced by KCI and Glutamate

  • Huang, Zhan-Bo (School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University) ;
  • Wu, Zhe (School of Pharmacy, Shenyang Pharmaceutical University) ;
  • Chen, Fa-Kui (School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University) ;
  • Zou, Li-Bo (School of Pharmacy, Shenyang Pharmaceutical University)
  • Published : 2006.11.30
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Abstract

Seven phenolic compounds (1-7) were isolated from the tubers of Gastrodia elata. Their structures were elucidated on the basis of MS and NMR spectral data. p-Ethoxymethyl phenyl-O-${\beta}$-D-glucoside (1) was proved to be a new compound, with N-(p-hydroxybenzyl)-adenosine (7) isolated from this plant for the first time. In this study, the protective effects of the six constituents (1-6) on PC12 cells against the cytotoxicity induced by KCI and glutamate were also investigated. The viability of the PC12 cells was significantly enhanced by pretreatment with the six phenolic constituents.

Keywords

References

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