Journal of Microbiology and Biotechnology

  • 제16권2호
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  • Pages.212-218
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  • 2006
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Occurrence of Microcystin-Containing Toxic Water Blooms in Central India

  • Agrawal Manish K. (Department of Biological Sciences, Rani Durgavati University) ;
  • Ghosh Shubhro K. (Department of Biological Sciences, Rani Durgavati University) ;
  • Bagchi Divya (Department of Biological Sciences, Rani Durgavati University) ;
  • Weckesser Juergen (Institut fur Biologie II, Mikrobiologie, Albert-Ludwigs Universitat) ;
  • Erhard Marcel (AnagnosTec GmbH) ;
  • Bagchi Suvendra N. (Department of Biological Sciences, Rani Durgavati University)
  • 발행 : 2006.02.01
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초록

Three out of fourteen Microcystis-dominant cyanobacterial blooms in Central India were found to be toxic to mice ($LD_{50}$ ranging from 35-450 mg bloom dry mass/kg body weight). The liver architecture of the treated mice showed characteristic symptoms of hepatotoxicity relative to the untreated controls, with increased enzyme activities of serum lactate dehydrogenase (LDH), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), and serum glutamate pyruvate transaminase (SGPT). RP-HPLC revealed the presence of microcystin-LR, microcystin-RR, and desmethyl microcystin-RR in the given region to maximum amounts of 390, 1,030, and $860{\mu}g/g$ bloom dry weight, respectively, corresponding to a maximum of 2.8 mg/l microcystin-LR in the lake water. Further confirmation of the microcystin variants was conducted using a MALDI-TOF MS analysis.

키워드

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