대한의생명과학회지 (Biomedical Science Letters)
- 제12권1호
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- Pages.29-33
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- 2006
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
A Protective Effect of Chlorella Supplementation on Cadmium-induced Nephrotoxicity in the Rats
- Hwang Yoo-Kyeong (Department of Biomedical Laboratory Science, Inje University) ;
- Choi Hyun-Jin (Department of Biomedical Laboratory Science, Inje University) ;
- Nan Meng (Department of Biomedical Laboratory Science, Inje University) ;
- Yoo Jai-Du (Department of Clinical Pathology, Masan College) ;
- Kim Yong-Ho (Department of Biomedical Laboratory Science, Inje University, Department of Biohealth Products Research Center, Inje University)
- 발행 : 2006.03.01
초록
The uptake of cadmium in animals is mainly accumulated in and affected to the liver and kidney by binding with red blood cells and serum albumin. The process accounts for more than 50% of the total accumulated cadmium in the body. The kidneys may be damaged without regarding the pathway uptake of cadmium. In a group of rats on supplements of 1% chlorella and 40 ppm cadmium, the concentration of cadmium in urine greatly decreased by 66% compared to control group, and the total synthesis of metallothionein decreased by 48.6% compared to control group. However, no previous study has assessed the protective effect on kidney damage induced by cadmium uptake through supplementation with chlorella. This study analyzed the biochemical marker for kidney damage in the rats after uptake of 40 ppm