Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
권호 표지

Effect of Mineral-induced Alkaline Reduced Water on Sprague-Dawley Rats Fed on High-fat Diet

  • Jin Dan (Department of Microbiology, Wonju College of Medicine, Yonsei University, Department of Microbiology and Immunology, Yanbian University College of Medicine) ;
  • Park Seung-Kyu (Department of Parasitology and Institutes for Basic Medical Science, Wonju College of Medicine, Yonsei University) ;
  • Lee Young-Mi (Biotech Research Institute, HDr Co., Ltd.) ;
  • Yoon Yang-Suk (Biotech Research Institute, HDr Co., Ltd.) ;
  • Kim Dong-Heui (Department of Basic Science, Wonju College of Medicine, Yonsei University) ;
  • Deung Young-Kun (Department of Basic Science, Wonju College of Medicine, Yonsei University) ;
  • Lee Kyu-Jae (Department of Parasitology and Institutes for Basic Medical Science, Wonju College of Medicine, Yonsei University)
  • Published : 2006.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

Mineral-induced alkaline-reduced water (MRW) is generated by the chemical reaction of water with alkaline earth metals and characterized by high pH and low oxidation-reduction potential. As ROS are believed to have a role in the pathogenesis of obesity, we attempted to determine the effect of MRW on obesity in Sprague-Dawley (SD) rats fed on a high-fat diet. The body weight of the MRW group was significantly lower than that of the control group in most periods of the examination (P<0.05). Serum level of triglycerides (p<0.05) and fat deposition in the livers of the MRW group were found to have been significantly reduced. This suggests that MRW down-regulates lipid metabolism, thereby suppressing obesity. Possible mechanisms of MRW related to reactive oxygen species were also discussed. Our results suggest that MRW is effective in the alleviation of obesity in SD rats fed on high-fat diet.

Keywords