Nutritional Sciences

The Korean Nutrition Society (한국영양학회)
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Effects of Copper, Zinc and Cadmium on the Recovery Pattern of Aryl Sulfotransferase IV Activity in Rats fed 2-Acetylaminofluorene Diet

  • Chung Keun Hee (Department of Food and Nutrition, Sahmyook University) ;
  • Ringel David P. (American Cancer Society) ;
  • Shin Kyung Ok (Department of Food and Nutrition, Sahmyook University)
  • Published : 2006.02.01
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Abstract

Purified rat liver aryl sulfotransferase IV (AST IV) was found to be inhibited in vitro by zinc, copper, cadmium and terbium. Among these four elements, zinc, copper and cadmium were all strongly inhibitory to the AST IV activity at very low concentrations (2.5 $\mu$M to 0.025 $\mu$M). In rat liver cytosol, zinc, copper and cadmium at 25 $\mu$M to 0.025 $\mu$M also decreased the AST IV activity to $50\%$ of the controls. In order to assess the possible effects of these metals on the AST IV activity recovery pattern in vivo, studies on the relationship between these minerals and dietary 2-acetylaminofluorene were conducted. Total of forty rats were fed one of five diets for 6 weeks: diet 1, Control diet plus 2-acetlyaminofluorene ($0.05\%$); diet 2, zinc-deficient diet plus 2-acetlyaminofluorene; diet 3, zinc-supplement diet plus 2-acetylaminofluorene; diet 4, copper-supplement diet plus 2-acetylaminofluorene; diet 5, cadmium-supplement diet plus 2-acetylaminofluorene. Half of the rats from each diet were changed to individual diet after 3 weeks of 2-acetylaminofluorene feeding. Placement of rats on the control diet following one cycle of 2-acetylaminofluorene feeding of 3 weeks without 2-acetylaminofluorene resulted in nearly full recovery of AST IV activity within 3 or 4 weeks. However, the rats fed diets that supplemented with zinc, copper or cadmium without 2-acetylaminofluorene showed a new pattern of lowered AST IV activity as early as the first cycle. Also, lowering in cytosolic AST IV contents was appeared in the livers from the rats, following one cycle of 2-acetylaminofluorene feeding of 3 weeks, fed one of the diets that supplemented with copper, cadmium or zinc without 2-acetylaminofluorene for ensuing 3 weeks.

Keywords

References

  1. Emmelot P, Scherer E. The first relevant cell stage in rat liver carcinogenesis. A quantitative approach. Biochim Biophys Acta 605(2):247-304, 1980
  2. Farber E, Sarma DS. Hepatocarcinogenesis: a dynamic cellular perspective. Lab Invest 56(1):4-22, 1987
  3. Sell S, Hunt JM, Knoll BJ, Dunsford HA. Cellular events during hepatocarcinogenesis in rats and the question of premalignancy. Adv Cancer Res 48:37-111, 1987 https://doi.org/10.1016/S0065-230X(08)60690-9
  4. Yuspa SH, Poirier Me. Chemical carcinogenesis:from animal models to molecular models in one decade. Adv Cancer Res 50:25-70, 1988 https://doi.org/10.1016/S0065-230X(08)60434-0
  5. Blanck A, Wicksell L, Eriksson LC. Sulfation of N-hydroxy-2-acetylaminofluorene in normal and modular liver from male Wistar rats. Toxicol Pathol 15(1):103-105, 1987 https://doi.org/10.1177/019262338701500115
  6. Deooum JR, Miller EC, Miller JA. N-hydroxy-2-acetylaminofluorene sulfotransferase: its probable role in carcinogenesis and ptrtein-(methion-S-yl)-binding in rat liver. Cancer Res 30(3):577-595, 1970
  7. Debaum JR, Rowley JY, Miller FC, Miller JA. Sulfotransferase activation of N-hydroxy-2-acetylaminofluorene in rodents liver susceptible and resistant to this carcinogen. Proc Soc Exp Biol Med 129(1):268-273, 1968 https://doi.org/10.3181/00379727-129-33301
  8. Irving CC. Comparative toxicity of N-hydroxy-2acetylaminofluorene in several strain of rats. Cancer Res 35(11 pt 1):2959-2961, 1975
  9. King CM, Phillips B. Enzyme-catabolized reactions of the carcinogen N-hydroxy-2-flutoenylavetamide with nucleic acid. Science 159(821):1351-1353, 1968 https://doi.org/10.1126/science.159.3821.1351
  10. Lai CC, Miller JA, Miller EC, Liem A. N-Sulfooxy-2-aminoflurene is the major ultimate electrophilic and carcinogenic metabolite of N-hydroxy-2-acetylaminofluorene in the livers of infant male C5BL/6J*C3H/HeJF1(BGC3F1)mice. Carcinogenesis 6(7):1037-1045, 1985 https://doi.org/10.1093/carcin/6.7.1037
  11. Meerman JHN, Mulder GJ. Prevention of the hepatotoxic action of N-hydroxy-2-acetylaminofluorene in the rats by inhibition of N-O-sulfation by pentachlorophenol. Life Sci 28(21):2361-2365, 1981 https://doi.org/10.1016/0024-3205(81)90501-4
  12. Mulder GI, Meerman JHN. Sulfation and gluconidation as competing pathways in the metabolism of hydroxamiv acids: the role of N, O-sulfonation in chemical carcinogensis of aromatic aminels. Environ Health Perspect 49:27-32, 1983 https://doi.org/10.2307/3429577
  13. Meerman JHN, Doom ABD, Muller OJ. Inhibition of sulfate conjugation of N-hydroxy-2-acetylanrinofluorene in isolated perfused rat liver and in the rat in vivo by pentachlorophenol and low sulfate. Cancer Res 40 (10):3772-3779, 1980
  14. Weisberger JH, Yamamoto RS, Williams OM, Oramtham PH, Matsushima T, Weisburger EK. Onthe sulfate ester of N-hydroxy-N-fluorenylacetanride as key ultimate hepatocarcinogen in the rat. Cancer Res 32(3):491-500, 1972
  15. Yamamoto RS, Olass RM, Frankel HH, Weisburger EK, Weisburger JH. Inhibition of the toxicity and carcinogenicity of N-2-fluorenylacetanride by acetamide. Toxicol Appl Pharmacol 13: 108-117, 1968 https://doi.org/10.1016/0041-008X(68)90139-7
  16. Yamamoto RS, Williams GM, Richardson HL, Weisburger EK, Weisburger JH. Effect of p-hydroxy-acetanilide on liver cancer induction by N-hydroxy-N-fluorenylacetamide. Cancer Res 33(3):454-457, 1973
  17. Ringer DP, Kampschnridt K, Jing RL, Jackson S, Kizer DE. Rapd decrease in N-hydroxy-2-acetylaminolfuorune sulfotransferase activity of liver cytosols from rats fed carcinogen. Biochem Pharmacol 32(2):315-319, 1983 https://doi.org/10.1016/0006-2952(83)90561-0
  18. Ringer DP, Nonon TR. Further characterization of the ability of hepatocarcinogens to lower rat liver aryl sulfotransferase activity. Carcinogenesis 8(11):1749-1752, 1987 https://doi.org/10.1093/carcin/8.11.1749
  19. Merrill J, Kim H, Safe S. Hymenoxon : biologic and toxic effects. Biochem Pharmacol 34(18):3383-3386, 1985 https://doi.org/10.1016/0006-2952(85)90363-6
  20. Muder GJ, Hinson JA, Gillette JR. Generation of reactive metabolites of N-hydroxy-phenacetin by glucuronidation and sulfation. Biochemical Pharmacology 26(3):189-196, 1977 https://doi.org/10.1016/0006-2952(77)90301-X
  21. Sekura RD, Jakoby WB. Aryl Sulfotransferase IV from rat liver. Arch Biochem Biophys 211 (1):352-359, 1981 https://doi.org/10.1016/0003-9861(81)90464-1
  22. Keen CL, Reinstein NH, Lefevre J, Lefevre M, Lonnerdal B, Scheeman BO, Hurley LS. Effect of dietary copper and zinc levels on tissue copper, zinc and iron in male rats. Biol Trace Elem Res 8:123-136, 1976 https://doi.org/10.1007/BF02917466
  23. Wu SG, Straub KD. Purficiation and characterization of N-hydroxy-2-acetylaminofluorene sulfotransferase from rat liver. J Biol Chem 251(21):6529-6536, 1976
  24. Hill CH, Matrone G. Chemical parameters in the study of in vivo and in vitro interactions of transition elements. Fed Proc 29(4):1474-1481, 1970
  25. Smith SE, Larson EJ. Zinc toxicity in rats and antagonistic effects of copper and silver. J Biol Chem 163:294-298, 1946
  26. Van Reen R. Effects of excessive dietary zinc in the rat and the interrelationship with copper. Arch Biochem Biophys 46(2):337-342, 1953 https://doi.org/10.1016/0003-9861(53)90206-9
  27. Matrone G, Hartman RH, Clawson AI. Studies of manganese-iron antagonism in the nutrition of rabbits and baby pigs. J Nutr 67(2):309-317, 1959 https://doi.org/10.1093/jn/67.2.309
  28. Supplee WC. Production of zinc deficiency in turkey poults by dietary cadmium. Poult Sci 40:827-828, 1961 https://doi.org/10.3382/ps.0400827
  29. Hill CH. Reversal of selenium toxicity in chicks by mercury, copper and cadmium. J Nutr 104(5):593-598, 1974 https://doi.org/10.1093/jn/104.5.593
  30. Peterson RP, Jensen LS. Interrelationships of dietary silver with copper in the chick. Poult Sci 54(3):771-775, 1975 https://doi.org/10.3382/ps.0540771
  31. Sheroeder HA, Mitchener M, Nason AP. Life-term effects of nickel in rats: Survival, tumors. Interaction with trace elements and tissue levels. J Nutr 104(2):239-243, 1974 https://doi.org/10.1093/jn/104.2.239
  32. Thomson A, Hansard SL, Bell MC. The influence of aluminum and zinc upon the absorption and retension of calcium and phosphorus in lambs. J Anim Sci 18:187-192, 1959 https://doi.org/10.2527/jas1959.181187x
  33. Compen DR. Copper interference with the interstitial absorption of zinc by rats. J Nutr 97 (1):104-108, 1970 https://doi.org/10.1017/S0007114507205781
  34. Van Compen DR, Scaife PU. Zinc interference with copper absorption in rat. J Nutr 91(4):473-476, 1967 https://doi.org/10.1093/jn/91.4.473
  35. Hafez YM, Kratzer PH. The effect of diet on the toxicity of vanadium. Poult Sci 55(3):918-922, 1976 https://doi.org/10.3382/ps.0550918
  36. Ringer DP, Norton TR, Boyd HW. 2-Acetylaminofluorene-mediated alterationin the level of liver arylsulfotransferase IV during rat hepatocarcinogenesis. Cancer Res 50(17):5301-5307, 1990