Nuclear Medicine and Molecular Imaging

The Korean Society of Nuclear Medicine (대한핵의학회)
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Evaluation of Therapeutic Effects of Cognitive-Behavioral Therapy in Patients with Panic Disorder using Serial $^{99m}Tc-ECD$ Brain Perfusion

공황장애 환자에서 $^{99m}Tc-ECD$ 뇌관류 SPECT를 이용한 인지행동치료 효과 평가

  • Kim, Jung-Hee (Departments of Nuclear Medicine, Chonnam National University Hospital) ;
  • Song, Ho-Chun (Departments of Nuclear Medicine, Chonnam National University Hospital) ;
  • Yang, Jong-Chul (Departments of Psychiatry, Chonnam National University Hospital) ;
  • Lee, Byeong-Il (Departments of Nuclear Medicine, Chonnam National University Hospital) ;
  • Heo, Young-Jun (Departments of Nuclear Medicine, Chonnam National University Hospital) ;
  • Bom, Hee-Seung (Departments of Nuclear Medicine, Chonnam National University Hospital) ;
  • Park, Tae-Jin (Department of Psychology, Chonnam National University) ;
  • Min, Jung-Joon (Departments of Nuclear Medicine, Chonnam National University Hospital)
  • 김정희 (전남대학교 의과대학 핵의학교실) ;
  • 송호천 (전남대학교 의과대학 핵의학교실) ;
  • 양종철 (전남대학교 의과대학 정신과) ;
  • 이병일 (전남대학교 의과대학 핵의학교실) ;
  • 허영준 (전남대학교 의과대학 핵의학교실) ;
  • 범희승 (전남대학교 의과대학 핵의학교실) ;
  • 박태진 (전남대학교 사회과학대학 심리학과) ;
  • 민정준 (전남대학교 의과대학 핵의학교실)
  • Published : 2006.12.31
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Abstract

Purpose: Although several neuroanatomical models of panic disorder have been proposed, little is known regarding the neurological mechanisms underlying cognitive-behavioral therapy (CBT) in patients with panic disorder. This study was performed to identify the brain structures that show changes of regnioal cerebral blood flow (rCBF) after CBT in patients with panic disorder. Materials and Methods: Seven patients who were diagnosed as panic disorder by DSM-IV were treated with CBT for 8 weeks and twelve healthy volunteers joined in this study. Serial $^{99m}Tc-ECD$ brain perfusion SPECT images were acquisited and PDSS-SR (Self-Report version of Panic Disorder Severity Scale) and ACQ (Agoraphobic Cognitive Question) scores were measured just before and after CBT in all patients. Data were analyzed using SPM2. Results: Subjective symptoms were improved, and PDSS-SR and ACQ scores were significantly reduced ($14.9{\pm}3.9\;vs.\;7.0{\pm}1.8$, p<0.05; $30.3{\pm}8.5\;vs.\;21.6{\pm}3.4$, p<0.05, respectively) after CBT in panic patients. Before CBT, a significant increase of rCBF was found in the cingulate gylus, thalamus, midbrain, both medial frontal and temporal lobes of the panic patients compared to the normal volunteers. After CBT, we observed a significant rCBF decrease in the left parahippocamus, right insula and cingulate gyrus, both frontal and temporal lobes, and a significant rCBF increase in both the occipital lobes, left insula, both frontal and left parietal lobes. Conclusion: These data suggested that CBT is effective for panic disorder and diminish the activity of the brain areas associated with fear in panic disorder.

목적: 공황장애에 대한 다양한 신경해부학적 모델들이 제안되었으나, 인지행동치료와 관련된 뇌 신경학적 기전에 대한 해석은 불명확하다. 본 연구에서는 공황장애 환자에서 CBT 전과 후에 뇌관류 변화를 평가하고 이에 따른 신경해부학적 연관성을 평가하고자 한다. 대상 및 방법: DSM-IV 기준으로 진단된 공황장애 환자 7명(남자 5명, 여자 2명, 평균연령 $45{\pm}11.0$세)을 대상으로 8주 동안 인지행동치료를 했으며, 건강한 정상인 12명(남자6명, 여자 6명, 평균연령 $42{\pm}9.5$세)을 대조군으로 사용하였다. 모든 환자들에게 인지행동치료 전과후에 $^{99m}Tc-ECD$ 뇌관류 SPECT, PDSS-SR과 ACQ점수를 각각 평가하였다. 인지행동치료 도중에는 약물치료를 실시하지 않았다. 모든 영상은 공간적으로 평준화와 편평화를 하여 SPM2를 이용하여 통계적으로 분석하였다. 결과: 공황장애 환자에서 인지행동치료 후 자각적인 증상들이 개선되고, 인지행동 평가 척도와 인지적 불안점수가 유의미하게 감소하였다(p<0.05). CBT치료 전에 띠이랑, 시상, 중간뇌와 전두엽과 측두엽에서 뇌관류가 증가하고, 우측 아래 전두엽에서 뇌관류가 감소함을 관찰하였다. 그리고 8주간의 CBT후 임상 소견의 호전과 함께 좌반구의 해마이랑, 우반구의 띠이랑와 도, 그리고 좌우 전두엽과 측두엽에서 뇌관류가 감소를 하였고 후두엽, 두정엽과 전두엽 일부에서 뇌관류가 증가한 소견을 관찰할 수 있었다. 결론: 공황장애 환자에서 약물치료 없이 인지행동치료만으로도 그 증상을 감소시키는 효과를 보였고, 이는 공포와 관련된 뇌영역에서 뇌활성도의 완화 및 안정화로 인해 치료 효과가 나타남을 알 수 있었다.

Keywords

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