자살을 시도한 우울증 환자에서 혈장 ${\beta}$-Nerve Growth Factor 농도의 변화

Alteration of Plasma ${\beta}$-Nerve Growth Factor Concentration in Depressed Patients with Suicidal Attempt

  • 심세훈 (순천향대학교 의과대학 천안병원 정신과학교실) ;
  • 원성두 (고려대학교 의과대학 안산병원 정신과학교실) ;
  • 이분희 (고려대학교 의과대학 안산병원 정신과학교실) ;
  • 한창수 (고려대학교 의과대학 안산병원 정신과학교실) ;
  • 양종철 (전남대학교 의과대학 전남대병원 정신과학교실) ;
  • 권영준 (순천향대학교 의과대학 천안병원 정신과학교실) ;
  • 김용구 (고려대학교 의과대학 안산병원 정신과학교실)
  • Shim, Se-Hoon (Department of Psychiatry, Soonchunhang University Cheon-An Hospital) ;
  • Won, Seong-Doo (Department of Psychiatry, College of Medicine, Korea University) ;
  • Lee, Bun-Hee (Department of Psychiatry, College of Medicine, Korea University) ;
  • Han, Chang Su (Department of Psychiatry, College of Medicine, Korea University) ;
  • Yang, Jong-Chul (Department of Psychiatry, Department of Psychiatry, Chonnam University Hospital) ;
  • Kwon, Young-Joon (Department of Psychiatry, Soonchunhang University Cheon-An Hospital) ;
  • Kim, Yong-Ku (Department of Psychiatry, College of Medicine, Korea University)
  • 발행 : 2006.05.31

초록

Object : Nerve growth factor(NGF) is a protein involved in neuronal survival and plasticity in the central nervous system, which might play an important role in stress, depression and suicide. This study was performed to determine whether there is an alteration in plasma NGF concentrations in depressed patients with suicidal attempt. Methods : The subjects were 32 depressed patients who attempted suicide and admitted in emergency room. Forty-four hospitalized non-suicidal depressive patients and the 30 normal controls were closely matched with the suicidal group in terms of age and sex. Individuals in all 3 groups were evaluated independently by a semi-structured interview for the purpose of establishing a DSM-IV criteria diagnosis. The severity of depressive symptoms was evaluated using Hamilton depression rating scale(HDRS). The severity of the suicidal behavior was evaluated by Weisman and Worden's risk-rescue rating(RRR) system and the Lethality Suicide Attempt Rating Scale(LSARS). Plasma NGF level was measured by the enzyme linked immunosorbent assay(ELISA) method. Results : There were no statistically significant differences of the plasma NGF levels among groups. LSARS and RRR did not reveal any significant correlation with ${\beta}$-NGF level in suicidal depressive patients. Conclusion : This study do not support an association between ${\beta}$-NGF and suicidal depression. However it is necessary to investigate this association through other route such as postmortem brain.

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