Journal of Nutrition and Health

  • 제39권1호
  • /
  • Pages.28-34
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  • 2006
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

여성 유방암 환자의 철, 구리, 아연 영양상태에 관한 연구

A Study on Zinc, Copper, Iron Nutritional Status of Women Patients with Breast Cancer in Korea

  • 천누리 (숙명여자대학교 식품영양학과) ;
  • 김은영 (숙명여자대학교 식품영양학과) ;
  • 배윤정 (숙명여자대학교 식품영양학과) ;
  • 승정자 (숙명여자대학교 식품영양학과)
  • Chun Noo-Ri (Department of Food & Nutrition, Sookmyung Women's University) ;
  • Kim Eun-Young (Department of Food & Nutrition, Sookmyung Women's University) ;
  • Bae Yun-Jung (Department of Food & Nutrition, Sookmyung Women's University) ;
  • Sung Chung-Ja (Department of Food & Nutrition, Sookmyung Women's University)
  • 발행 : 2006.01.01
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초록

This study was performed to compare nutrients intake and levels of three elements (iron, copper and zinc) in the plasma of breast cancer patients to those in healthy controls. Patients (n = 97) and their age-matched healthy control groups (n = 97) participated in the study. A semi-quantitative food frequency questionnaire specifically formulated to evaluate the consumption of nutrients was used to estimate dietary intake. Only plasma was taken from the 20 patients and their age-matched healthy control group. Plasma concentrations of iron, copper, zinc, ratio of Cu/Zn were measured in both groups. Results showed that patients consumed significantly lower protein, fat, iron. Plasma level of copper and ratio of Cu/Zn were significantly higher in patients compared to those of controls. In conclusion, change of trace elements in plasma might be useful and significant as biomakers involving the initial process. And these results imply that trace elements status is a factor related to breast cancer risk and suggest that proper intake of those nutrients is required for cancer prevention.

키워드

참고문헌

  1. 보건복지부. 한국인 암등록 조사 자료 분석 보고서. 서울, 2002
  2. Zhai H, Chen X, Hu Z. Study on the relationship between intake of trace elements and breast cancer mortality with chemometric methods. Comput Biol Chem 27(6): 581-586, 2003 https://doi.org/10.1016/S1476-9271(03)00049-5
  3. Boyd NF, McGuire V. The possible role of lipid peroxidation in breast cancer risk. Free Radic Biol Med 10(3-4): 185-190, 1991 https://doi.org/10.1016/0891-5849(91)90074-D
  4. Davis DL, Pongsiri MJ, Wolff M. Recent developments on the avoidable causes of breast cancer. Ann N Y Acad Sci 837: 513- 523, 1997 https://doi.org/10.1111/j.1749-6632.1997.tb56896.x
  5. Abdulla M, Biorklund A, Mathur A, Wallenius K. Zinc and copper levels in whole blood and plasma from patients with squamous cell carcinomas of head and neck. J Surg Oncol 12(2): 107-113, 1979 https://doi.org/10.1002/jso.2930120203
  6. Machacek J. Serum levels of Cu and Zn in breast cancer and its possible using in clinical practice. News Clin Oncol 6: 112-116, 1984
  7. Huang YL, Sheu JY, Lin TH. Association between oxidative stress and changes of trace elements in patients with breast cancer. Clin Biochem 32(2): 131-136, 1999 https://doi.org/10.1016/S0009-9120(98)00096-4
  8. Kuo HW, Chen SF, Wu CC, Chen DR, Lee JH. Serum and tissue trace elements in patients with breast cancer in Taiwan. Biol Trace Elem Res 89(1): 1-11, 2002 https://doi.org/10.1385/BTER:89:1:1
  9. Ministery of Health and Walfare. 2001 National nutrition survey report, 2002
  10. The Korean Nutrition Society. Dietary reference intake for Koreans. KDRIs. Korea, 2005
  11. Monsen ER. Iron nutrition and absorption: dietary factors which impact iron bioavailability. J Am Diet Assoc 88(7): 786-790, 1988
  12. Cook JD, Monsen ER. Food iron absorption in human subjects. III. Comparison of the effect of animal proteins on nonheme iron absorption. Am J Clin Nutr 29(8): 859-867, 1976 https://doi.org/10.1093/ajcn/29.8.859
  13. Heimo S, Friedrich S, Walter SS. Food Composition and Nutrition Tables. CRC Press, 1994
  14. 대한비만학회. 2002 비만의 진단과 치료; 아시아-태평양 지역 지침. 대한비만학회, 2002
  15. Do MH, Lee SS, Jung PJ, Lee MH. Food Intake and Breast Cancer Risk: A Case - Control Study. Korean J Nutr 34(2): 165-175, 2001
  16. Cavallo F, Gerber M, Marubini E, Richardson S, Barbieri A, Costa A, DeCarli A, Pujol H. Zinc and copper in breast cancer. A joint study in northern Italy and southern France. Cancer 67 (3): 738-745, 1991 https://doi.org/10.1002/1097-0142(19910201)67:3<738::AID-CNCR2820670335>3.0.CO;2-#
  17. Lee DH, Anderson KE, Harnack LJ, Folsom AR, Jacobs DR Jr. Heme iron, zinc, alcohol consumption, and colon cancer: Iowa Women's Health Study. J Natl Cancer Inst 96(5): 403-407, 2004 https://doi.org/10.1093/jnci/djh047
  18. Herrinton LJ, Friedman GD, Baer D, Selby JV. Transferrin saturation and risk of cancer. Am J Epidemiol 142(7): 692-698, 1995 https://doi.org/10.1093/oxfordjournals.aje.a117698
  19. Wu T, Sempos CT, Freudenheim JL, Muti P, Smit E. Serum iron, copper and zinc concentrations and risk of cancer mortality in US adults. Ann Epidemiol 14(3): 195-201, 2004 https://doi.org/10.1016/S1047-2797(03)00119-4
  20. Ulbrich EJ, Lebrecht A, Schneider I, Ludwig E, Koelbl H, Hefler LA. Serum parameters of iron metabolism in patients with breast cancer. Anticancer Res 23(6D): 5107-5109, 2004
  21. Chung YD, Hong SI, Na HB, Shim YH. The study on concentration of serum copper and zinc in stomach cancer patients. Korean J Nutr 24(6): 516-525, 1991
  22. Zowczak M, Iskra M, Torlinski L, Cofta S. Analysis of serum copper and zinc concentrations in cancer patients. Biol Trace Elem Res 82(1-3): 1-8, 2001 https://doi.org/10.1385/BTER:82:1-3:001
  23. Bao SF. Clinical significance of serum copper/zinc ratio in diagnosis for recurrent breast cancer. Met Ion Biol 5: 578-582, 1998