Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Calcium and Boron Intakes on Calcium Balance Status in Ovariectomized Rats

난소절제 흰쥐에 있어 칼슘과 보론 섭취수준이 칼슘 평형상태에 미치는 영향

  • Choi, Mi-Kyeong (Dept. of Human Nutrition & Food Science, Chungwoon University) ;
  • Kim, Mi-Hyun (Dept. of Food & Nutrition, Samcheok National University) ;
  • Kang, Myung-Hwa (Dept. of Food Science & Nutrition, Hoseo University)
  • 최미경 (청운대학교 식품영양학과) ;
  • 김미현 (삼척대학교 식품영양학과) ;
  • 강명화 (호서대학교 식품영양학과)
  • Published : 2006.01.01
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Abstract

This study was conducted to investigate the effect of calcium and boron intakes on calcium utilization in ovariectomized (OVX) rats. Rats were divided into 9 groups and fed diets containing various levels of calcium $(0.1\%,\;0.5\%,\;1.5\%)$ and boron (0.5 ppm, 50 ppm, 100 ppm) for 4 weeks. The half of rats in each group were ovariectomized and the others were sham-operated. Rats were fed same diets for 8 weeks after operation. Feed intake and weight gain were significantly increased as the dietary calcium was increased and those of OVX group were higher than in sham-operated group. Feed efficiency ratio was significantly higher in OVX group than that in sham-operated one. With boron supplementation, serum calcium level was significantly increased in low-calcium group, but decreased in adequate/high-calcium group. In calcium balance, calcium intake was significantly increased with increasing levels of calcium and boron and higher in OVX group than that in sham-operated one. With increasing calcium intake, fecal and urinary calcium excretions were significantly increased. Urinary calcium excretion was significantly decreased with increment of boron intake. Apparent calcium absorption of adequate-calcium OVX group was the highest among the groups. Daily calcium retention was significantly increased as the dietary calcium was increased and that of high-calcium OVX group was higher than high-calcium sham-operated group. According to these results, the boron supplementation increased the calcium intake and decreased the urinary calcium excretion. Therefore, it could be suggested that the boron supplementation may be complementary to calcium nutrition and useful for bone health.

우리나라는 노인인구의 증가에 따라 골다공증과 같은 골격질환자가 증가하고 있으며 국민 식생활 평가에서 칼슘섭취의 부족이 좀처럼 해결되지 못하고 있다. 보론이 식물성 식품에 풍부하다는 연구결과를 고려할 때 식물성 식품을 많이 섭취하는 우리나라에서 칼슘과 보론과의 관계를 규명하는 연구는 매우 필요하다고 생각한다. 따라서 본 연구에서 흰쥐를 대상으로 칼슘과 보론의 섭취수준을 달리하여 4주간 사육한 후 난소절제군과 비절제군으로 나눠 다시 8주간 사육하여 칼슘과 보론의 섭취수준이 칼슘평형에 미치는 영향을 살펴보았다. 사료섭 취 량과 체중증가량은 칼슘 섭취량이 높을수록, 난소절제군이 비절제군보다 높았다. 사료효율은 난소절제군이 비절제군보다 높았다. 혈청 중 칼슘 함량은 보론 보충에 따라 저칼슘군에서는 증가하였으나 적정과 고칼슘군에서는 감소하였다. 칼슘평형에서 칼슘 섭취량은 칼슘과 보론 섭취량이 높고 난소 적출을 한 경우 높은 것으로 나타났다. 대변 중 배설량은 난소 절제와 비절제군 모두 칼슘 섭취량이 증가할수록 높았으며, 소변 중 배설량은 칼슘 섭취량이 높을수록 증가한 반면, 보론 보충에 따라서는 감소하였다. 칼슘의 겉보기 흡수율은 칼슘 적정군과 난소절제군이 다른 군보다 높았으며, 칼슘 보유량은 칼슘 섭취량이 증가할수록 고칼슘군에서 난소절제군이 비절제군보다 높았다. 이상의 연구결과를 종합할 때 칼슘의 섭취량이 증가할수록 대변 중 칼슘 배설량이 증가하였지 만 칼슘 보유량은 증가하였고 칼슘의 겉보기 흡수율은 적정 칼슘군이 가장 높았다. 보론의 보충에 따라 칼슘의 겉보기 흡수율과 보유량은 유의한 변화가 없었지만 칼슘 섭취량은 증가하고 소변 중 칼슘 배설량은 감소하여 보론은 칼슘만큼 뚜렷한 영향은 아니지만, 체내의 칼슘이용을 촉진하고 배설을 감소시킴으로써 골격건강에 유용한 작용을 하는 것으로 나타났다.

Keywords

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