References
- Altschul, S., T. Madden, A. Schaffer, J. H. Zhang, Z. Zhang, W. Miller, and D. Lipman. 1997. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402 https://doi.org/10.1093/nar/25.17.3389
- Amann, R. I., W. Ludwig, and K. H. Schleifer. 1995. Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol. Rev. 59: 143- 169
- Aparicio, J. F., R. Fouces, M. V. Mendes, N. Olivera, and J. F. Martin. 2000. A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis. Chem. Biol. 11: 895- 905
- August, P. R., L. Tang, Y. J. Yoon, S. Ning, R. Muller, T.-W. Yu, M. Taylor, D. Hoffmann, C.-G. Kim, X. Zhang, R. Hutchinson, and H. G. Floss. 1998. Biosynthesis of the ansamycin antibiotic rifamycin: Deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chem. Biol. 5: 69-79 https://doi.org/10.1016/S1074-5521(98)90141-7
- Courtois, S., C. M. Cappellano, M. Ball, F. Francou, P. Normand, G. Helynck, A. Martinez, S. J. Kolvek, J. Hopke, M. S. Osburne, P. R. August, R. Nalin, M. Guerineau, P. Jeannin, P. Simonet, and J. Pernodet. 2003. Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products. Appl. Environ. Microbiol. 69: 49-55 https://doi.org/10.1128/AEM.69.1.49-55.2003
- Daniel, R. 2004. The soil metagenome - a rich resource for the discovery of novel natural products. Curr. Opin. Biotech. 15: 199-204 https://doi.org/10.1016/j.copbio.2004.04.005
- Ginohac, A., C. Jarrin, B. Gillet, P. Robe, P. Pujic, K. Tuphile, H. Bertrand, T. M. Vogel, G. Perriere, P. Simonet, and R. Nalin. 2004. Phylogenetic analysis of polyketide synthase I domains from soil metagenomic libraries allows selection of promising clones. Appl. Environ. Microbiol. 70: 5522-5527 https://doi.org/10.1128/AEM.70.9.5522-5527.2004
- Hong, J. S. J., C. Y. Choi, and Y. J. Yoon. 2003. Premature release of polyketide intermediates by hybrid polyketide synthase in Amycolatopsis mediterrnei S699. J. Microbiol. Biotechnol. 13: 613-619
- Hopwood, D. A. and D. H. Sherman. 1990. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Annu. Rev. Genet. 24: 37-66 https://doi.org/10.1146/annurev.ge.24.120190.000345
- Kim, C.-Y., H.-J. Park, and U.-S. Kim. 2003. Heterologous expression of hybrid type II polyketide synthase system in Streptomyces species. J. Microbiol. Biotechnol. 13: 819- 822
- Lee, S. K., C. Y. Choi, J. S. Ahn, K. Y. Cho, C. S. Park, and Y. J. Yoon. 2004. Identification of a cytochrome P450 hydroxylase gene involved in rifamycin biosynthesis by Amycolatopsis mediterranei S699. J. Microbiol. Biotechnol. 14: 356-362
- Peric-Concha, N. and P. F. Long. 2003. Mining the microbial metabolome: A new frontier for natural product lead discovery. Drug Discov. Today 23: 1078-1084
- Reeves, A. R., R. S. English, J. S. Lampel, D. A. Post, and T. J. Vanden Boom. 1999. Transcriptional organization of the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea. J. Bacteriol. 181: 7098-7106
- Rondon, M. R., P. R. August, A. D. Bettermann, S. F. Brady, T. H. Grossman, M. R. Liles, K. A. Loiacono, B. A. Lynch, L. A. MacNeil, C. Minor, C. L. Tiong, M. Gilman, M. S. Osburne, J. Clardy, J. Handelsman, and R. M. Goodman. 2000. Cloning the soil metagenome: A strategy for accessing the genetic and functional diversity of uncultured microorganisms. Appl. Environ. Microbiol. 66: 2541-2547 https://doi.org/10.1128/AEM.66.6.2541-2547.2000
- Santi, D. V., M. A. Siani, B. Julien, D. Kupfer, and B. Roe. 2000. An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: A search for the epothilone gene cluster. Gene 247: 97-102 https://doi.org/10.1016/S0378-1119(00)00113-X
- Schwecke, T., J. F. Aparicio, I. Molnar, A. Konig, L. E. Khaw, S. F. Haycock, M. Oliynyk, P. Caffrey, J. Cortes, J. B. Lester, G. A. Bohm, J. Staunton, and P. F. Leadlay. 1995. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc. Natl. Acad. Sci. USA 92: 7839-7843
- Seok, J. W., E. S. Kim, H. Y. Kang, C. Y. Choi, D. H. Sherman, and Y. J. Yoon. 2003. Site-directed mutagenesis on putative macrolactone ring size determinant in the hybrid pikromycin-tylosin polyketide synthase. J. Microbiol. Biotechnol. 13: 823-827
- Silakowski, B., H. U. Schairer, H. Ehret, B. Kunze, S. Weinig, G. Nordsiek, P. Brandt, H. Blocker, G. Hofle, S. Beyer, and R. Muller. 1999. New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1. J. Biol. Chem. 274: 37391-37399 https://doi.org/10.1074/jbc.274.1.3
- Streit, W. R. and R. A. Schmitz. 2004. Metagenomics: The key to the uncultured microbes. Curr. Opin. Microbiol. 7: 492-498 https://doi.org/10.1016/j.mib.2004.08.002
- Tang, L., S. Shah, L. Chung, J. Carney, L. Katz, C. Khosla, and B. Julien. 2000. Cloning and heterologous expression of the epothilone gene cluster. Science 287: 640-642 https://doi.org/10.1126/science.287.5453.640
- Watve, M. G., R. Tickoo, M. M. Jog, and B. D. Bhole. 2001. How many antibiotics are produced by the genus Streptomyces? Arch. Microbiol. 176: 386-390 https://doi.org/10.1007/s002030100345
- Yadav, G., R. S. Gokhale, and D. Mohanty. 2003. SEARCHPKS: A program for detection and analysis of polyketide synthase domains. Nucleic Acids Res. 31: 3654- 3658 https://doi.org/10.1093/nar/gkg607