Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Effect of Exopolymers of Aureobasidium pullulans on Improving Osteoporosis Induced in Ovariectomized Mice

  • SONG HEBOK (TG Biotech Research Institute, Kyungpook National University) ;
  • PARK DONG CHAN (TG Biotech Research Institute, Kyungpook National University) ;
  • DO GYUNG MIN (TG Biotech Research Institute, Kyungpook National University) ;
  • HWANG SEUNG-LARK (TG Biotech Research Institute, Kyungpook National University) ;
  • LEE WON KYU (TG Biotech Research Institute, Kyungpook National University) ;
  • KANG HEUN-SOO (Metabolic Engineering Laboratories) ;
  • PARK BOK-RYUN (Glucan Co., Bio 21 Center) ;
  • JANG HEE-JEONG (Glucan Co., Bio 21 Center) ;
  • SONG CHANG-WOO (Glucan Co., Bio 21 Center) ;
  • PARK EUI KYUN (Skeletal Diseases Genome Research Center, Biomedical Research Institute, Kyungpook National University Hospital) ;
  • KIM SHIN-YOON (Department of Orthopedic Surgery, Biomedical Research Institute, Kyungpook National University, Hospital) ;
  • HUH TAE-LIN (Kyungpook National University, Department of Genetic Engineering)
  • Published : 2006.01.01
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Abstract

Treatment with exopolymers of Aureobasidium pullulans SM-2001 containing $\beta-1,3/1,6-glucan$ inhibited osteoclastogenesis of bone marrow stem cells in a co-culture system with calvariae osteoblastic cells. In addition, the treatment increased mineral deposition in osteoblastic cells. These two observations prompted us to evaluate whether the exopolymers could be used as an anti-osteoporotic agent, and efficacy of the exopolymers to prevent bone loss was compared with alendronate, a bisphosphonate, in ovariectomized mice prone to osteoporosis. Administration of the exopolymers to the ovariectomized mice resulted in improved effects on femur weight and histomorphometric changes of femur such as trabecular bone volume (TBV), trabecular bone thickness (TBT), and cortical bone thickness (CBT). In conclusion, the exopolymers treatment inhibited bone loss from osteoporosis induced by ovariectomy, and the effect was comparable to alendronate administration.

Keywords

References

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