생명과학회지 (Journal of Life Science)

  • 제16권1호
  • /
  • Pages.156-161
  • /
  • 2006
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
DOI QR코드

DOI QR Code

감송향 정유성분의 흡입 및 경구투여시의 중추신켱 억제효과

Inhibitory Effects of the Essential Oil from Nardostachys intamansi on Central Nervous System after Inhalation and Oral Administration

  • 구병수 (동국대학교 한의과대학 신경정신과) ;
  • 김대근 (동국대학교 한의과대학 신경정신과) ;
  • 최정현 (동국대학교 자연과학대학 생명공학과) ;
  • 이동웅 (동국대학교 자연과학대학 생명공학과)
  • Koo Byung-Soo (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Kim Dae-kun (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Choi Jung-Hyun (Department of Biotechnology, College of Natural Science, Dongguk University) ;
  • Lee Dong-Ung (Department of Biotechnology, College of Natural Science, Dongguk University)
  • 발행 : 2006.02.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The essential oil of Nardostachys jatamansi (Valerianaceae), which has been used for a long time in aroma therapy, was investigated after inhalation or oral administration for its analgesic effect, anticonvulsant action, hypnotic effect and in vitro inhibitory activity on monoamine oxidase. This fragrance oil showed a significant analgesic effect in the phenylquinone-induced .writhing test, suppressed the convulsion induced by pentylenetetrazole and lengthened the pentobarbital-induced sleeping time in a time-dependent manner after fragrance inhalation or dose-independently by oral administration. Its inhibitory activity on monoamine oxidase was remarkable, showing $49.4\%$ inhibition at a concentration of 5.0 mg/ml. Six new terpenes with seven known compounds were detected by our GC-MS analytical conditions used. As a result, the essential oil fragrance of Nardostachys jatamansi would be clinically useful for a sedative by either inhalation or oral administration.

키워드

참고문헌

  1. Bircher, R. P., T. Kanai and S. C. Wang. 1962. Intravenous, cortical and intraventricular dose-effect relationship of pentylenetetrazol, picrotoxin and deslanoside in dogs. Electroencephalogr. Clin. Neurophysiol. 14, 256-267 https://doi.org/10.1016/0013-4694(62)90035-4
  2. Bose, B. C., S. S. Gupta, J. N. Bhatnagar and R. Vijayvargiya. 1957. Nardostachys Jatamansi DC: its sedative and depressant action as estimated by Warburg technique. Indian Journal of Medical Sciences 11, 803-807
  3. Chatterjee, A., B. Basak, U. Datta, J. Banerji, A. Neuman and T. Prange. 2005. Studies on the chemical constituents of Nardostachys jatamansi DC (Valerianaceae). Ind. J. Chem. Section B: Organic Chemistry Including Medicinal Chemistry 44B, 430-433
  4. Gupta, S. S., C. B. Patel and V. S. Mathur. 1961. Effect of Nardostachys jatamansi fumes and aerosols in histamineinduced bronchial asthma in guinea pigs. Journal of the Indian Medical Association 37, 223-225
  5. Hendershot, L.C. and J. Forsaith. 1959. Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics. J. Pharm. Exptl. Therap. 125, 237-240
  6. Jouvet, M. 1969. Biogenic amines and the states of sleep: pharmacological and neurophysiological studies suggest a relationship between brain serotonin and sleep. Science 163, 32-41 https://doi.org/10.1126/science.163.3862.32
  7. Koo, B. S., K. S. Park, J. H. Ha, J. H. Park, J. C. Lim and D. U. Lee. 2003. Inhibitory Effects of the Fragrance Inhalation of Essential Oil from Acorus gramineus on Central Nervous System. Biol. Pharm. Bull. 26, 978-982 https://doi.org/10.1248/bpb.26.978
  8. Koo, B. S., S. I. Lee, J. H. Ha and D. U. Lee. 2004. Inhibitory Effects of the Essential Oil from SuHeXiang Wan on the Central Nervous System after Inhalation. Biol. Pharm. Bull. 27, 515-519 https://doi.org/10.1248/bpb.27.515
  9. Kusuhara, H., H. Matsuyuki and T. Okumoto. 1998. Involvement of prosta-glandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone. Prostaglandins & Other Lipid Mediators 55, 43-49 https://doi.org/10.1016/S0090-6980(98)00004-5
  10. Li, P., K. Matsunaga and Y. Ohizumi. 1999. Enhancement of the nerve growth factor-mediated neurite outgrowth from PC12D cells by Chinese and Paraguayan medicinal plants. Biol. Pharm. Bull. 22, 752-755 https://doi.org/10.1248/bpb.22.752
  11. Mahalwal, V. S. and M. Ali. 2002. Volatile constituents of the rhizomes of Nardostachys jatamansi DC. Journal of Essential Oil-Bearing Plants 5, 83-89
  12. Metcalf, B. W. 1979. Inhibitors of GABA metabolism. Biochem. Pharmacol. 28, 1705-1712 https://doi.org/10.1016/0006-2952(79)90529-X
  13. Mishra, D., R. V. Chaturvedi and S. C. Tripathi. 1995. The fungitoxic effect of the essential oil of the herb Nardostachys jatamansi DC. Tropical Agriculture 72, 48-52
  14. Namba, T. 1993. The Encyclopedia of Wakan-Yaku(Traditional Sino-Japanese Medicines) with Color Pictures. Vol. 1. pp. 50-51. Hoikusa. Osaka, Japan
  15. Oh, H. J. 1996. Study on the literatures of aroma therapy. Hyehwaeuihak 5, 261-281
  16. Ohishi, S., A. Ueno, H. Matsumoto, T. Murata, F. Ushikubi and H. Narumiya. 1999. Evidence for involvement of prostaglandin I2 as a major ociceptive mediator in acetic acid-induced writhing reaction: A study using IP-receptor disrupted mice. Advances in Experimental Medicine and Biology 469, 265-268 https://doi.org/10.1007/978-1-4615-4793-8_39
  17. Rao, J. T. 1986. Antimicrobial properties of the essential oil of Nardostachys jatamansi. PAFAI Journal 8, 27-28
  18. Salim, S., M. Ahmad, K. S. Zafar, A. S. Ahmad and F. Islam. 2003. Protective effect of Nardostachys jatamansi in rat cerebral ischemia. Pharmacol. Biochem. Behav. 74, 481-486 https://doi.org/10.1016/S0091-3057(02)01030-4
  19. Schuckit, M. A. 1981. Current therapeutic options in the management of anxiety. J. Clin. Psychiat. 42, 15-24
  20. Singh, V. and M. Ali. 2003. New phytoconstituents from Nardostachys jatamansi rhizomes. Journal of Saudi Chemical Society 7, 119-128
  21. Sommer, C. 2004. Serotonin in pain and analgesia : Actions in the periphery. Mol. Neurobiol. 30, 117-125 https://doi.org/10.1385/MN:30:2:117
  22. Tabor, C.W., H. Tabor and S. M. Rosenthal. 1954. Purification of amine oxidase from beef plasma. J. Biol. Chem. 208, 645-661
  23. Thomas, P. S. 1995. The colorful past and future of monoamine oxidase research, pp. 1-22, In Yu, P. M., K. F. Tipton and A. A. Boulton (eds), Progress in Brain Research. Current neurochemical and pharmacological aspects of biogenic amines, Elsevier, Amsterdam
  24. Tita, B., H. Abdel-Haq, A. Vitalone, G. Mazzanti and L. Saso. 2001. Analgesic properties of Epilobium angustifolium, evaluated by the hot plate test and the writhing test. Farmaco., 56, 341-343 https://doi.org/10.1016/S0014-827X(01)01046-1